Results 191 to 200 of about 10,934,305 (297)

Spatial control over near-critical-point operation ensures fidelity of ParABS-mediated DNA partition. [PDF]

Biophys J, 2021
Hu L, Rech J, Bouet JY, Liu J.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Replacing critical point drying with hexamethyldisilazane drying enhances the ultrastructural preservation of cell surface projections in the parasite Trichomonas vaginalis for scanning electron microscopy. [PDF]

PLoS One
Dos Santos Melo T, Miranda-Magalhães A, Celia Bressan Queiroz de Figueiredo R, Pereira-Neves A.   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Maximal isometric and eccentric hamstring strength is influenced by body mass and additional load: Does the critical point at which peak knee flexor force is achieved play a role? [PDF]

Front Physiol
Sinulingga AR, Zemková E.
europepmc   +1 more source

Functional advantages of Lévy walks emerging near a critical point. [PDF]

Proc Natl Acad Sci U S A, 2020
Abe MS.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Ferromagnetic quantum critical point protected by nonsymmorphic symmetry in a Kondo metal. [PDF]

Nat Commun
Shin S, Ramires A, Pomjakushin V, Plokhikh I, Pomjakushina E.   +4 more
europepmc   +1 more source

Ultra-Narrow Metallic Nano-Trenches Realized by Wet Etching and Critical Point Drying. [PDF]

Nanomaterials (Basel), 2021
Jeong J, Yang H, Park S, Park YD, Kim DS.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source