Results 171 to 180 of about 2,485,751 (313)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Finding critical points whose polarization is also a critical point

, 2012
We show that near any given minimizing sequence of paths for the mountain pass lemma, there exists a critical point whose polarization is also a critical point. This is motivated by the fact that if any polarization of a critical point is also a critical
Van Schaftingen, Jean, Squassina, Marco
core  

A critical point in chiral chromatography-mass spectrometry analysis of ketamine metabolites. [PDF]

Drug Test Anal, 2021
Barbarossa A, Bardhi A, Gazzotti T, Pagliuca G.   +3 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Superlinear fractional boundary value problems without the Ambrosetti-Rabinowitz condition

Electronic Journal of Differential Equations, 2018
In this article, by means of a direct variational approach and the theory of the fractional differential space, we prove the existence of a nontrivial solution for superlinear fractional boundary value problems without Ambrosetti and Rabinowitz ...
Bin Ge, Jian-Fang Lu, Ting-Ting Zhao, Kang Zhou   +3 more
doaj  

Comparison of temperature and doping dependence of elastoresistivity near a putative nematic quantum critical point. [PDF]

Nat Commun, 2022
Palmstrom JC, Walmsley P, Straquadine JAW, Sorensen ME, Hannahs ST, Burns DH, Fisher IR.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Critical point-based wireless sensors enabling tiny perturbation detection. [PDF]

Sci Adv
Ma C, Yin K, Zhang Z, Huang R, Huang Y, Gan L, Liu Y, Xia F, Xia T, Chen Y, Li W, Peng LM, Dong T, Hu Y.   +13 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Disclosing the True Critical Point of Fluids Confined in Nanopores. [PDF]

Langmuir
Owusu-Banahene EK, Tan SP, Dejam M, Adidharma H.   +3 more
europepmc   +1 more source