Spatial control over near-critical-point operation ensures fidelity of ParABS-mediated DNA partition. [PDF]
Biophys J, 2021 Hu L, Rech J, Bouet JY, Liu J.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Replacing critical point drying with hexamethyldisilazane drying enhances the ultrastructural preservation of cell surface projections in the parasite Trichomonas vaginalis for scanning electron microscopy. [PDF]
PLoS OneDos Santos Melo T +3 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Maximal isometric and eccentric hamstring strength is influenced by body mass and additional load: Does the critical point at which peak knee flexor force is achieved play a role? [PDF]
Front PhysiolSinulingga AR, Zemková E.
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Functional advantages of Lévy walks emerging near a critical point. [PDF]
Proc Natl Acad Sci U S A, 2020 Abe MS.
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Ferromagnetic quantum critical point protected by nonsymmorphic symmetry in a Kondo metal. [PDF]
Nat CommunShin S +4 more
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Ultra-Narrow Metallic Nano-Trenches Realized by Wet Etching and Critical Point Drying. [PDF]
Nanomaterials (Basel), 2021 Jeong J +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source