Results 141 to 150 of about 2,485,751 (313)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Every point is critical

, 2013
We show that, for any compact Alexandrov surface S (without boundary) and any point y in S, there exists a point x in S for which y is a critical point. Moreover, we prove that uniqueness characterizes the surfaces homeomorphic to the sphere among smooth
Jin-ichi Itoh, Bárány, Imre, Imre Bárány, Tudor Zamfirescu, Zamfirescu, T., Itoh, J.-I., Costin Vîlcu, Vîlcu, C.   +7 more
core   +1 more source

Pure nematic quantum critical point accompanied by a superconducting dome. [PDF]

Proc Natl Acad Sci U S A, 2022
Ishida K, Onishi Y, Tsujii M, Mukasa K, Qiu M, Saito M, Sugimura Y, Matsuura K, Mizukami Y, Hashimoto K, Shibauchi T.   +10 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Critical Point-of-care Ultrasound Diagnosis of Fournier's Gangrene: A Case Report. [PDF]

Clin Pract Cases Emerg Med, 2022
Ramm L, Guidry K, Cirilli A, Kurkowski E, Yu C.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The breakdown of both strange metal and superconducting states at a pressure-induced quantum critical point in iron-pnictide superconductors. [PDF]

Nat Commun, 2023
Cai S, Zhao J, Ni N, Guo J, Yang R, Wang P, Han J, Long S, Zhou Y, Wu Q, Qiu X, Xiang T, Cava RJ, Sun L.   +13 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modelación de la carga para estudios estáticos de estabilidad de tensión; Modelling of the load for stable state studies of voltage stability

Revista Científica de Ingeniería Energética, 2013
En este trabajo se presenta un análisis de la influencia de la naturaleza de la carga en la estabilidad de tensión. El margen de carga es un índice considerado exacto para el análisis de la estabilidad de la tensión, sin embargo tradicionalmente se ha ...
Zaid Garcia Sánchez, José Antonio González-Cueto Cruz, Leonardo Casas Fernández, Juan Gualberto Boza Valerino   +3 more
doaj  

Thermodynamic Derivation of Scaling at the Liquid-Vapor Critical Point. [PDF]

Entropy (Basel), 2021
Obeso-Jureidini JC, Olascoaga D, Romero-Rochín V.   +2 more
europepmc   +1 more source