Results 211 to 220 of about 11,033,430 (362)

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Existence and multiplicity of solutions for a Dirichlet problem involving perturbed p(x)-Laplacian operator

open access: yesElectronic Journal of Differential Equations, 2016
In this article we study the existence of solutions for the Dirichlet problem $$\displaylines{ -\text{div}(| \nabla u |^{p(x)-2}\nabla u)+V(x)|u|^{q(x)-2}u =f(x,u)\quad \text{in }\Omega,\cr u=0\quad \text{on }\partial \Omega, }$$ where $\Omega$ is
Aboubacar Abdou, Aboubacar Marcos
doaj  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Existence of multiple solutions to elliptic problems of Kirchhoff type with critical exponential growth

open access: yesElectronic Journal of Differential Equations, 2014
In this article, we study elliptic problems of Kirchhoff type in dimension $ N \geq 2$, whose nonlinear term has a critical exponential growth. Using variational tools, we establish the existence of at least two nontrivial and nonnegative solutions.
Sami Aouaoui
doaj  

Critical Point-Finding Methods Reveal Gradient-Flat Regions of Deep Network Losses. [PDF]

open access: yesNeural Comput, 2021
Frye CG   +5 more
europepmc   +1 more source

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