Results 211 to 220 of about 16,818,507 (390)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Ready or not, here we come: framing nutrition prescribing rights and responsibilities

The South African Journal of Clinical Nutrition
Lauren T Hill
doaj   +1 more source

Comparison of temperature and doping dependence of elastoresistivity near a putative nematic quantum critical point. [PDF]

Nat Commun, 2022
Palmstrom JC, Walmsley P, Straquadine JAW, Sorensen ME, Hannahs ST, Burns DH, Fisher IR.   +6 more
europepmc   +1 more source

Critical point analysis of dielectric constant in ZnO thin films on different electronic environments

, 2019
Muhammad Abiyyu Kenichi Purbayanto, Rafi Ichwan, Eka Nurfani, Yudi Darma   +3 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Homoclinic solutions for second-order non-autonomous Hamiltonian systems without global Ambrosetti-Rabinowitz conditions

Electronic Journal of Differential Equations, 2010
This article studies the existence of homoclinic solutions for the second-order non-autonomous Hamiltonian system $$ ddot q-L(t)q+W_{q}(t,q)=0, $$ where $Lin C(mathbb{R},mathbb{R}^{n^2})$ is a symmetric and positive definite matrix for all $tin ...
Rong Yuan, Ziheng Zhang
doaj  

Femtosecond control of phonon dynamics near a magnetic order critical point. [PDF]

Nat Commun, 2021
Gorobtsov OY, Ponet L, Patel SKK, Hua N, Shabalin AG, Hrkac S, Wingert J, Cela D, Glownia JM, Zhu D, Medapalli R, Chollet M, Fullerton EE, Artyukhin S, Shpyrko OG, Singer A.   +15 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View. [PDF]

Int J Mol Sci, 2021
Nicoară SD, Brie I, Jurj A, Sorițău O.   +3 more
europepmc   +1 more source