Results 41 to 50 of about 2,179,018 (268)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Existence of periodic solutions with prescribed minimal period of a 2nth-order discrete system
Open Mathematics, 2019 In this paper, we concern with a 2nth-order discrete system. Using the critical point theory, we establish various sets of sufficient conditions for the existence of periodic solutions with prescribed minimal period. To the best of our knowledge, this is
Liu Xia, Zhou Tao, Shi Haiping
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Electronic Journal of Differential Equations, 2010 This article studies the existence of homoclinic solutions for the second-order non-autonomous Hamiltonian system $$ ddot q-L(t)q+W_{q}(t,q)=0, $$ where $Lin C(mathbb{R},mathbb{R}^{n^2})$ is a symmetric and positive definite matrix for all $tin ...
Rong Yuan, Ziheng Zhang
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Wild Recurrent Critical Points [PDF]
Journal of the London Mathematical Society, 2005 It is conjectured that a rational map whose coefficients are algebraic over $\Q_p$ has no wandering components of the Fatou set. R. Benedetto has shown that any counter example to this conjecture must have a wild recurrent critical point. We provide here the first examples of rational maps whose coefficients are algebraic over $\Q_p$ and that have a ...
openaire +3 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
A Brezis-Nirenberg problem on hyperbolic spaces
Electronic Journal of Differential Equations, 2019 We consider a Brezis-Nirenberg problem on the hyperbolic space $\mathbb{H}^n$. By using the stereographic projection, the problem becomes a singular problem on the boundary of the open ball $B_1(0)\subset \mathbb{R}^n$. Thanks to the Hardy inequality,
Paulo C. Carriao +3 more
doaj
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Relations between the mountain pass theorem and local minima
Advances in Nonlinear Analysis, 2012 Existence results of two critical points for functionals unbounded from below are established after pointing out a characterization of the mountain pass geometry. Applications to elliptic Dirichlet problems are then presented.
Bonanno Gabriele
doaj +1 more source