Results 251 to 260 of about 1,806,849 (306)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
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Why Bond Critical Points Are Not “Bond” Critical Points
Chemistry – A European Journal, 2018AbstractEquating (3,−1) critical points (CPs), derived from the topological analysis of the electron densities, to chemical bonds has triggered a lot of confusion in recent years. Part of this confusion stems from calling these CPs “bond” CPs (BCPs). While the origin of this terminology is traceable to the late seventies and beginning of eighties, when
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Critical Point in Complex Plasmas
Physical Review Letters, 2006The occurrence of liquid-vapor phase transition and the possible existence of a critical point in complex plasmas--systems that consist of charged micrograins in a neutralizing plasma background--is investigated theoretically. An analysis based on the consideration of the intergrain interaction potential suggests that under certain conditions systems ...
Khrapak, S. +8 more
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Physical Review B, 1987
Already within Landau theory with short-ranged substrate-adsorbate forces, complete wetting is not necessary near critical points. Preferential adsorption, but only partial wetting all the way to the critical point, and even critical-point dewetting are possible.
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Already within Landau theory with short-ranged substrate-adsorbate forces, complete wetting is not necessary near critical points. Preferential adsorption, but only partial wetting all the way to the critical point, and even critical-point dewetting are possible.
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Percolation and critical points
Journal of Physics: Condensed Matter, 2001The interplay between critical percolating clusters and critical points in physical systems and models is reviewed. The main emphasis is given to systems such as colloids and gels. Much information on the main mechanism leading to percolation in correlated systems can be obtained from the study of the Ising model.
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1981
To fix the notation, we consider the interaction $$V\left( \phi \right) = \lambda \phi ^4 + \sigma \phi ^2 - \mu \phi $$ (17.1.1) with λ, σ, and μ real and 0 0.)
James Glimm, Arthur Jaffe
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To fix the notation, we consider the interaction $$V\left( \phi \right) = \lambda \phi ^4 + \sigma \phi ^2 - \mu \phi $$ (17.1.1) with λ, σ, and μ real and 0 0.)
James Glimm, Arthur Jaffe
openaire +1 more source