Results 131 to 140 of about 4,716,782 (236)
Formalism and Realism in Ruins (Mapping the Logics of Collapse)
Теоретическая и прикладная юриспруденцияAfter laying out a conventional account of the formalism vs. realism debates, this Article argues that formalism and realism are at once impossible and entrenched.
P. Shlag
doaj +1 more source
Humean Perspectives on Structural Realism [PDF]
, 2009 The paper is a kind of opinionated review paper on current issues in the debate about Structural Realism, roughly the view that we should be committed in the structural rather than object-like content of our best current scientific theories.
Lyre, Holger
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Neoliberalism and the Mutations of Social Realism in Contemporary European Cinema
Cinéma & CieOver the last couple of decades film scholars have begun building a critical vocabulary to theorize the new kinds of social relations depicted in the new European cinema of precarity, from “flexible solidarity” and “precarious intimacies” to “the gift ...
Temenuga Trifonova
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, 2017 Popular music life is permeated by a quantitative form of male dominance, and has been for several decades. Based on a recent study this article engages with the reproduction of said male dominance by attempting to understand boys’ approaches to popular ...
Kvarnhall, Victor,
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Practical Realism: Against Standard Scientific Realism and Anti-Realism
Studia Philosophica Estonica, 2012 In this paper, the elaboration of the concept of practical realist philosophy of science which began in the author's previous papers is continued.
Rein Vihalemm
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source