Results 31 to 40 of about 219 (184)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Air-pressure response characteristics and instability precursor identification of vacuum-suction karst collapse

Zhongguo dizhi zaihai yu fangzhi xuebao
Karst ground collapse is highly sudden, concealed, and difficult to monitor and warn against. This study analyzes the air-pressure response and precursory characteristics of covered karst collapse under vacuum-suction conditions.
Hao YU, Jingyi LI, Sheng GONG, Fan SUN, Cong CAO, Zhi LIU, Boyi LI, Xun JIANG   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Observation of critical scaling in spin glasses below Tc using thermoremanent magnetization

Frontiers in Physics
Time-dependent thermoremanent magnetization (TRM) studies have been instrumental in probing energy dynamics within the spin glass phase. In this paper, we review the evolution of the TRM experiment over the last half century and discuss some aspects ...
G. G. Kenning, M. Brandt, R. Brake, M. Hepler, D. Tennant   +4 more
doaj   +1 more source

The Critical Slowing of Algorithms in LQCD Simulations

Albanian Journal of Natural and Technical Sciences, 2023
Chiral symmetry plays a critical role in lattice QCD simulations, particularly in modelling strong interactions. Simulations involving chiral fermions are computationally demanding due to the intricacies of the chiral Dirac operator.
Dafina Xhako, Suela Hoxhaj, Niko Hyka, Rudina Zeqirllari, Enkelejd Çaça   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Study on the fracture behavior and critical slowing down characteristics of saturated sandstone based on acoustic emission and resistivity

Scientific Reports
Water significantly affects the fracture behavior and acoustic emission (AE) characteristics of sandstone, which is crucial for assessing the stability of underground engineering.
Yantao Zheng, Changwu Liu, Kunpeng Lu, Hexing Zhang, Bingxi Jian, Wuzhou Zhang   +5 more
doaj   +1 more source

Tensile shear fracture evolution and critical slowing down early warning in roadway rockburst processes

采矿与岩层控制工程学报
To investigate the crack evolution mechanism and precursor characteristics of rockburst, granite roadway rockburst simulation experiments were conducted using a true triaxial testing machine.
Peng LIANG, Yao LU, Yanbo ZHANG, Xulong YAO, Guangyuan YU, Qiang HAN   +5 more
doaj   +1 more source