Results 51 to 60 of about 219 (184)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Mechanical response and failure precursors of sandstone under freeze-thaw cycling with varying saturation

International Journal of Mining Science and Technology
In cold-region rock engineering, freeze-thaw (F-T) cycles and varying saturation levels significantly influence rock mechanical behavior and failure precursors.
Shenghui Huang, Chaoyun Yu, Haineng Shi, Zhixiang Liu, Jiahui Huang, Junfeng Wang   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Linking network- and neuron-level correlations by renormalized field theory

Physical Review Research
It is frequently hypothesized that cortical networks operate close to a critical point. Advantages of criticality include rich dynamics well suited for computation and critical slowing down, which may offer a mechanism for dynamic memory.
Michael Dick, Alexander van Meegen, Moritz Helias   +2 more
doaj   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Diffusion models as stochastic quantization in lattice field theory

Journal of High Energy Physics
In this work, we establish a direct connection between generative diffusion models (DMs) and stochastic quantization (SQ). The DM is realized by approximating the reversal of a stochastic process dictated by the Langevin equation, generating samples from
L. Wang, G. Aarts, K. Zhou
doaj   +1 more source

Spatiotemporal dynamics and key climatic influences on vegetation resilience in opencast coal mine dumps after restoration

International Journal of Applied Earth Observations and Geoinformation
Vegetation resilience is crucial for understanding the self-repair and adaptive capacity of regional ecosystems. Opencast coal mine dumps, typical targets for ecological restoration, exhibit highly unstable vegetation ecosystems after restoration, making
Hui Wang, Chengye Zhang, Yaxin Ding, Feiyue Li, Wanxi Liu, Yan Ma, Yingjie Guo, Bikram Banerjee, Jun Li   +8 more
doaj   +1 more source

Critical Dynamics of the k-Core Pruning Process

Physical Review X, 2015
We present the theory of the k-core pruning process (progressive removal of nodes with degree less than k) in uncorrelated random networks. We derive exact equations describing this process and the evolution of the network structure and solve them ...
G. J. Baxter, S. N. Dorogovtsev, K.-E. Lee, J. F. F. Mendes, A. V. Goltsev   +4 more
doaj   +1 more source