Results 41 to 50 of about 13,106,141 (277)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2021 Community residents possess first-hand knowledge of the community and effective execution of retrofit methods. Their understanding, acceptance and ultimately participation determine the smoothness of working process and the success of the project ...
Qian, QK (author) +3 more
core
Critical Success Factors in Construction Projects (Governmental Projects as a Case Study)
Journal of Engineering, 2016 The importance of the construction sector and its Great role in the provision of services and infrastructure, reduce poverty, improve living conditions and improve the economic situation in the country, impose attention to the way in which the projects ...
Hatem Khaleefah Al-Ageeli, Ass. Prof. Dr. +1 more
doaj
Identifying program critical success factors in construction industry [PDF]
Management Science Letters, 2014 In project management literature, the concept of program is a group of related projects managed in a coordinated way to obtain benefits not available from managing them individually.
Sarmad Kiani +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Critical success factors for accounting information systems data quality [PDF]
, 2003 Quality information is critical to organisations’ success in today’s highly competitive environment. Accounting information systems (AIS) as a discipline within information systems require high quality data. However, empirical evidence suggests that data
Xu, Hongjiang
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Six Sigma in construction: a review of critical success factors
, 2016 Purpose This paper aims at collecting and reviewing the published literature on the Six Sigma in construction along with its critical success factors (CSFs). Design/methodology/approach The research is based on literature review.
Ullah, Fahim +3 more
core +1 more source