Results 61 to 70 of about 2,640,634 (298)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Critical success factors of ERP implementation in SMEs [PDF]

open access: yesJournal of Project Management, 2019
This paper is aimed at reviewing present state of the art (1998-March 2019) on the impact of Enterprise Resource Planning (ERP) implementation in Small and Medium Enterprises (SMEs). It includes critical success factors and critical failure factors.
Talluri Sai Kiran, A Vasudeva Reddy
doaj   +1 more source

Implementation of critical success factors in construction research and development process [PDF]

open access: yes, 2010
Construction research and development (R&D) process has a number of issues that affect its success. These issues imply that Critical Success Factors (CSFs) of construction R&D process are not properly addressed.
Amaratunga, RDG, Haigh, RP, Kulatunga, U
core  

Critical Success Factors for Building Information Modelling Implementation [PDF]

open access: yes, 2018
Adoption of Building Information Modelling (BIM) in the global construction industry is fast growing. This paper expounds the Critical Success Factors (CSFs) for BIM implementation and explore their ranking and underlying relationships.
Amuda-Yusuf, Ganiyu
core   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

An evaluation of the current urban design process in order to derive critical success factors for the creation of a potential new urban design process framework [PDF]

open access: yes, 2015
The current urban design process is top-down, i.e., generally the urban designers or planners design the urban environment and at a later stage the community may have some involvement. There are serious criticisms of this process as it may not touch the “
Amaratunga, Dilanthi   +3 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Factors determining the success of public private partnership projects in Nigeria [PDF]

open access: yes, 2016
The implementation of public private partnership (PPP) procurement method is expected to help governments in the development of infrastructures and provides an opportunity for the reduction in the governments’ debt profiles.
Sanni, Afeez Olalekan
core   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Overcoming SMEs Challenges through Critical Success Factors: A Case of SMEs in the Western Cape Province, South Africa [PDF]

open access: yesEconomic and Business Review, 2014
SMEs comprise over 90% of African business operations and contribute to over 50% of African employment and Growth Domestic Product (GDP). SMEs sector has shown positive signs in South Africa, Mauritius and North Africa.
Takalani Ramukumba
doaj  

Home - About - Disclaimer - Privacy