Endometrial immune dysregulation shapes CD8<sup>+</sup> T cell mediated reproductive outcomes in recurrent implantation failure: an integrated mechanistic and predictive analysis. [PDF]
Jiang S +7 more
europepmc +1 more source
1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications
In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth +2 more
wiley +1 more source
The impact of CSF gusher on preservation of low frequency residual hearing following cochlear implantation. [PDF]
Fatima G +5 more
europepmc +1 more source
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle +6 more
wiley +1 more source
The Role of Immunological Bystander Reaction in Recurrent Pregnancy Loss. [PDF]
Lakhno I.
europepmc +1 more source
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Macrophage plasticity in the osteosarcoma tumor microenvironment: opportunities and challenges for immunotherapy. [PDF]
Li H, Liu C, Zhang B, Zhang Y, Liu Y.
europepmc +1 more source
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Host-directed immune therapies: a second front in the battle against sepsis. [PDF]
Hotchkiss RS, Monneret G.
europepmc +1 more source
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett +7 more
wiley +1 more source

