Applying critical systems thinking to social prescribing: a relational model of stakeholder "buy-in". [PDF]
BMC Health Serv Res, 2020 Fixsen A, Seers H, Polley M, Robins J.
europepmc +1 more source
Four domains of complexity [PDF]
, 2016 In this short paper, which reflects on one of my contributions to the systems literature in 1992 (Pluralism and the Legitimation of Systems Science), I discuss the context at that time.
Midgley, Gerald
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Ecosystem properties and principles of living systems as foundation for sustainable agriculture – Critical reviews of environmental assessment tools, key findings and questions from a course process [PDF]
, 2002 With increasing demands on limited resources worldwide, there is a growing interest in sustainable patterns of utilisation and production. Ecological agriculture is a response to these concerns.
Ekbladh, G. +5 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Addressing organisational and societal concerns : an application of critical systems thinking to information systems planning in Colombia [PDF]
Most current information system s (IS) planning methodologies are focused on achieving ‘successful’ plans, i.e. plans that provide competitive advantage, can be implemented in a given period of time, and that solve the problems of information needs by ...
Córdoba-Pachon, José-Rodrigo +1 more
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Visual Literacy and New Technologies [PDF]
, 2003 This body of research addresses the connection between arts, identity and new technology, and investigates the impact of images on adolescent identities, the relationship between online modes of communication and cyber-bullying, the increasing ...
Bamford, Anne
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Cultivation of the Students’ Critical Thinking Ability in Numerical Control Machining Course Based on the Virtual Simulation System Teaching Method [PDF]
, 2020 Yongxiang Li +3 more
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