Results 121 to 130 of about 1,110,179 (310)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Analytics for Protecting Critical Infrastructure

, 2015
In this paper we review the key trends related to application of information technology and, in particular, automated data analysis to the problem of protecting critical infrastructure.
Adam Zagorecki, Jozef Ristvej, Krzysztof Klupa   +2 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Managing technology development for safety-critical systems [PDF]

This paper presents a model that determines the optimal budget allocation strategy for the development of new technologies for safety-critical systems over multiple decision periods.
Sachon, Marc, Paté-Cornell, Elisabeth
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Harmonizing Urban Innovation: Exploring the Nexus between Smart Cities and Positive Energy Districts

Energies
The emergence of the Smart City concept in Europe in the early 2010s emphasized the enhancement of livability and sustainability in urban environments through the integrated use of data and sensors as tools for designing comprehensive governance ...
Paola Clerici Maestosi
doaj   +1 more source

Primary production and recycling of critical metals

, 2019
Metals are important engineering materials, and are produced from non-renewable natural resources. This chapter starts with the criticality and scarcity issue of metals and metal resources.
Yang, Y. (author)
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluation of Predictive Markers for Immunotherapy in Colorectal Cancer: Concordance Between MMR Protein Expression and Microsatellite Instability in a Retrospective Series

Journal of Molecular Pathology
Background/Objectives: In metastatic colorectal cancer (mCRC) the evaluation of mismatch repair (MMR) and microsatellite instability (MSI) status is essential to identify patients eligible for treatment with immune-checkpoint inhibitors (ICI). This study
Giulia Martinelli, Rossella Bruno, Marco Maria Germani, Anello Marcello Poma, Paola Vignali, Chiara Cremolini, Clara Ugolini   +6 more
doaj   +1 more source

The critical need for creative technologies education

This chapter explains the crucial need for teachers to advance the technological creativity of students, based on the accelerating influence of technology upon almost every facet of society, the need for digital design capabilities in the workplace, the ...
Lee, Jihyun, Bower, Matt, Falloon, Garry, Wang, Tianchong   +3 more
core   +1 more source