Results 111 to 120 of about 1,110,179 (310)
HeliyonDaqu is usually produced in an open environment, which makes its quality unstable. The microbial community of Daqu largely determines its quality. Therefore, in order to improve the fermentation characteristics of Daqu, samples were collected from Jinsha
Yijie Dai, Lei Yu, Jintao Ao, Rui Wang
doaj +1 more source
Keeping up with the 'digital natives': Integrating Web 2.0 technologies into classroom practice.
, 2008 This report describes a self-study using an action research spiral of problem analysis, intervention design, trial, reflection and analysis. The main purpose of the study was to investigate and evaluate whether Web 2.0 technologies and, in particular ...
Cleary, Alison
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Challenges and Ethical Considerations in Implementing Assistive Technologies in Healthcare
Assistive technologies are becoming an increasingly important aspect of healthcare, particularly for people with physical or cognitive problems. While earlier research has investigated the ethical, legal, and societal implications of AI and assistive ...
Eleni Gkiolnta +2 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Defense Technologies: DOD's Critical Technologies Lists Rarely Inform Export Control and Other Policy Decisions [PDF]
, 2006 A letter report issued by the Government Accountability Office with an abstract that begins "Major acquisitions in the Department of Defense's (DOD) force transformation rely on maintaining technological superiority to ensure U.S.
United States. Government Accountability Office.
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Semantic Technologies and Enhanced Situation Awareness
, 2007 Situation awareness is a critical element of military decision superiority in a wide variety of operational contexts. Improved situation awareness can benefit operational effectiveness by facilitating the planning process, improving the quality and ...
Bahrami, Ali +5 more
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