Results 101 to 110 of about 613,818 (299)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
O debate da Teoria Crítica sobre a tecnologia
Ciências Sociais Unisinos, 2017 The article is divided into three parts. In the first part we commented on the central problematizations about the question of technology in authors of the first generation of Critical Theory – namely in Theodor Adorno and Max Horkheimer, and Herbert ...
Ednei de Genaro
doaj
Revisiting Post-May 1968 French Theory: Critical Thought and Data Capitalism
Anglica. An International Journal of English StudiesThis essay explores the critical crisis stemming from the normalization of data-driven capitalism in the neoliberal era. It proposes the concept of subjectivization of anachronism, developed by French philosophers in the 1960s, as a potential avenue for ...
Alex Taek-Gwang Lee
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What Is in the Cloud? A Critical Engagement with Thomas Metzger on “The Clash between Chinese and Western Political Theories” [PDF]
, 2007 Jiwei Ci
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Lélia Gonzalez: an Amefrican perspective to reorient the canon
TapuyaThis paper is centered on the contribution by Lélia Gonzalez, a marginalized, Black Brazilian intellectual who was a professor from the 1970s to the 1990s until prematurely passing away in 1994.
Stefan Klein, Mariana Toledo Ferreira
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Nonlinear Theory of Sound Waves near Critical Points. III: -- First Order Phase Transition under Periodic Temperature -- [PDF]
, 1982 Akira Ōnuki
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source