Results 101 to 110 of about 4,281,061 (233)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
International Journal of COPDYan Chen,1 Xinli Li,2 Dongni Hou,3 Wenhao Li,4 Zhike Liu,4 Meng Zhang,4 IokFai Cheang,2 Peng Shen,5 Hongbo Lin,5 Siyan Zhan,4 Feng Sun,4 Yuanlin Song3,6– 8 1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South ...
Chen Y +11 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Bildung, capabilities, human freedom and human flourishing
Journal of Comparative Social WorkThere is international interest in approaches to social work focussing on human development and service users’ real freedoms to act. One such example, established in social work, is the capabilities approach.
Magnus Frampton +2 more
doaj +1 more source
The Criticism of Standard and the Standard of Criticism [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2017 Criticism is a natural and humane phenomenon, and it originates from human’s willingness to freedom. Thought is the mental moving from the base to the result and visa-versa. So, this action is subject to evaluation and criticism.
Gholamreza Fadaie
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Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
[Review of] Patricia Hill Collins. Fighting Words: Black Women & The Search For Justice [PDF]
, 1998 Collins\u27 Fighting Words builds on her previous work, Black Feminist Thought, as she explores standpoint theory and the outsider within position and their usefulness for Black feminist thought.
Patton, Venetria K.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Political Economic Approach to Old Age: The Carroll Estes Model
SenectusAging, a crucial concern within social policy and services, has gained increasing attention from scholars and policymakers because of the accelerating global demographic shift toward the aging population.
Elif Çevik
doaj +1 more source