Results 101 to 110 of about 9,680,109 (207)

Black feminism and Artificial Intelligence: the possibilities and limitations of contesting discriminatory AI from a critical social theory perspective

Frontiers in Sociology
Artificial Intelligence (AI) has been challenged in recent years by critical scholars inspired by American Black feminism and questions around diversity, inclusion, and justice in and through AI systems.
Laura Schelenz
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Critical theory and transformative learning: Some insights

, 2019
Critical theory and transformative learning are two seminal theories that have incited a deluge of literature, fueled many discussions, and triggered much debate.
Torrisi-Steele, Geraldine, Wang, Victor X, Hansman, Catherine A   +2 more
core   +1 more source

Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database

International Journal of COPD
Yan Chen,1 Xinli Li,2 Dongni Hou,3 Wenhao Li,4 Zhike Liu,4 Meng Zhang,4 IokFai Cheang,2 Peng Shen,5 Hongbo Lin,5 Siyan Zhan,4 Feng Sun,4 Yuanlin Song3,6– 8 1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South ...
Chen Y, Li X, Hou D, Li W, Liu Z, Zhang M, Cheang I, Shen P, Lin H, Zhan S, Sun F, Song Y   +11 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Lélia Gonzalez: an Amefrican perspective to reorient the canon

Tapuya
This paper is centered on the contribution by Lélia Gonzalez, a marginalized, Black Brazilian intellectual who was a professor from the 1970s to the 1990s until prematurely passing away in 1994.
Stefan Klein, Mariana Toledo Ferreira
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Du kitsch en théorie

Itinéraires
Based on the work of Walter Benjamin, the paper focuses on the notion of kitsch, considered as a category for discourse analysis. First, it discusses several levels of analysis of kitsch in discourse. Secondly, it proceeds to a reading of Walter Benjamin’
François Provenzano
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

History, Literature, Critical Theory

In this book, Dominick LaCapra continues his exploration of the complex relations between history and literature, considering history as both process and representation.Intro -- History, Literature, Critical Theory -- Contents -- Introduction -- 1.
LaCapra, Dominick.
core