Results 121 to 130 of about 1,318,024 (302)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Assessing trainee critical thinking skills using a novel interactive online learning tool. [PDF]

Med Educ Online, 2023
Jantausch BA, Bost JE, Bhansali P, Hefter Y, Greenberg I, Goldman E.   +5 more
europepmc   +1 more source

Working the Nexus: Teaching students to think, read and problem-solve like a lawyer [PDF]

, 2016
Despite a clear case for thinking skills in legal education, the approach to teaching these skills often appears to be implied in law curricula rather than identified explicitly.
Galloway, Kathrine, Heath, Mary, Hewitt, Anne, Israel, Mark, Skead, Natalie, Steel, Alex   +5 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Artificial Intelligence-Generated Content Empowers College Students’ Critical Thinking Skills: What, How, and Why

Education Sciences
Despite the increasing number of studies indicating that generative artificial intelligence is conducive to cultivating college students’ critical thinking skills, research on the impact of college students’ use of generative artificial intelligence on ...
Weiping Zhang, Xinxin Liu
doaj   +1 more source

Learning critical thinking skills online: can precision teaching help? [PDF]

Educ Technol Res Dev, 2023
Tan AJY, Davies JL, Nicolson RI, Karaminis T.   +3 more
europepmc   +1 more source

Improving critical thinking of students: A great challenge in clinical nursing education. [PDF]

, 2011
Introduction: With regards to the importance and role of critical thinking in nursing , especially in clinical setting, achieving this goal(improving critical thinking) is very important. So nursing teachers encounter with the challenge of how asisting
Etemadifar, Shahram., Haghani, Fariba., maghsoudi, Jahangir.   +2 more
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Teaching critical thinking skills in Rwandan secondary schools: challenge and practical solutions

Cogent Education
Many university graduates struggle with critical thinking due to weak secondary school preparation, affecting their independent reasoning and decision-making.
Laurien Tuyishimire, Wallace Mlaga, Patrice Ntawigira   +2 more
doaj   +1 more source