Results 51 to 60 of about 3,454 (266)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
“Kill ‘em with Kindness”: Midwest Nice as a Mechanism of Whiteness
Education Sciences“Midwest Nice” is a phrase used to capture the Nice, friendly, and courteous demeanor often associated with people who live or were raised in the Midwest region of the United States.
Emilie Homan
doaj +1 more source
Saying One Thing and Doing Another: Whiteness and Education in the Neoliberal Era
Journal of Curriculum Theorizing, 2018 This essay uses students’ consideration of their high school’s mission statement—an equity statement meant to foster multiculturalism—to consider whiteness and education in the neoliberal era.
Samuel Jaye Tanner
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
'Wit' armoede en 'wit' bevoorregting in enkele Afrikaanse jeugromans
Literator, 2019 ‘White’ poverty and ‘white’ privilege in selected Afrikaans novels for young adults. This article examines the representation of ‘white’ poverty in selected Afrikaans novels for young adults published between 1990 and 2014: Droomwa (1990) by Barrie Hough,
Loraine van der Westhuizen +1 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
ConviviumDer Beitrag zielt darauf, auf theoretischer Ebene den Einfluss der Postcolonial Studies, Critical Whiteness Studies und Black Studies auf die postmigrantische Literatur deutlich zu machen.
Martina Kofer
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source