Results 71 to 80 of about 3,194,109 (321)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

“Kill ‘em with Kindness”: Midwest Nice as a Mechanism of Whiteness

Education Sciences
“Midwest Nice” is a phrase used to capture the Nice, friendly, and courteous demeanor often associated with people who live or were raised in the Midwest region of the United States.
Emilie Homan
doaj   +1 more source

Saying One Thing and Doing Another: Whiteness and Education in the Neoliberal Era

Journal of Curriculum Theorizing, 2018
This essay uses students’ consideration of their high school’s mission statement—an equity statement meant to foster multiculturalism—to consider whiteness and education in the neoliberal era.
Samuel Jaye Tanner
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

'Wit' armoede en 'wit' bevoorregting in enkele Afrikaanse jeugromans

Literator, 2019
‘White’ poverty and ‘white’ privilege in selected Afrikaans novels for young adults. This article examines the representation of ‘white’ poverty in selected Afrikaans novels for young adults published between 1990 and 2014: Droomwa (1990) by Barrie Hough,
Loraine van der Westhuizen, Jacomien van Niekerk   +1 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

“Decolonize your mind” – Narrative Entmachtungsstrategien von race und whiteness in MITHU SANYALS Identitti und SHIDA BAZYARS Drei Kameradinnen

Convivium
Der Beitrag zielt darauf, auf theoretischer Ebene den Einfluss der Postcolonial Studies, Critical Whiteness Studies und Black Studies auf die postmigrantische Literatur deutlich zu machen.
Martina Kofer
doaj   +1 more source

Pedagogies of Race: The Politics of Whiteness in an African American Studies Course [PDF]

, 2011
This paper evaluates students\u27 arguments for a color-blind society to avoid discussions related to the continued existence of racism in USA culture.
Jones, Regina V.
core   +1 more source