Results 51 to 60 of about 4,650,992 (309)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Deep Learning with UAV Imagery for Subtropical Sphagnum Peatland Vegetation Mapping
Remote SensingPeatlands are vital for global carbon cycling, and their ecological functions are influenced by vegetation composition. Accurate vegetation mapping is crucial for peatland management and conservation, but traditional methods face limitations such as low ...
Zhengshun Liu, Xianyu Huang
doaj +1 more source
Ecological and Genomic Attributes of Novel Bacterial Taxa That Thrive in Subsurface Soil Horizons
mBio, 2019 While most bacterial and archaeal taxa living in surface soils remain undescribed, this problem is exacerbated in deeper soils, owing to the unique oligotrophic conditions found in the subsurface.
Tess E. Brewer +24 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Frontiers in Water, 2020 Climate warming in alpine regions is changing patterns of water storage, a primary control on alpine plant ecology, biogeochemistry, and water supplies to lower elevations.
Anna L. Hermes +10 more
doaj +1 more source
, 2020 With the emergence of the global shift issue, the observation of natural environments is developing in keeping with a national and international strategy.
openaire +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 2021 Our contemporary world is filled with sensors, from weather stations to infrasound facilities and seismic monitoring stations. These sensors constitute a specific spatial and architectural reality in the Critical Zone and introduce the idea of the ...
Brouwer, Menno (author)
core
Managing agency for athletic performance: a discursive approach to the zone [PDF]
, 2008 This paper provides a discursive perspective on a concept used within sport psychology, in both its academic and practical discourse, namely 'the zone.' This extraordinary state is one of exceptional peak performance whereby an athlete claims to perform ...
Abigail Locke, Locke, Abigail
core +1 more source