Results 121 to 130 of about 992,630 (344)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Cuadernos de Proyectos Arquitectónicos, 2015 ResumenPara la portada de este libro el autor ha elegido un dibujo muy atinado. Se trata de una ilustración de Saul Steinberg, arquitecto de formación e ilustrador de ofi cio, en el que se ve un cubo trazado en perspectiva axonométrica ligeramente ...
Fernando Quesada
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Hybrid Graph Hydrodynamic Method for Modelling Multiple Pipe Failure in Stormwater Networks
Engineering ProceedingsModelling multiple pipe failure scenarios in stormwater networks is a challenging task due to the computational burden of conventional methods. In this context, this study proposes a hybrid graph hydrodynamic model (GHM) that combines the advantages of ...
Aun Dastgir +4 more
doaj +1 more source
A critical review of guidelines for low back pain treatment [PDF]
, 2005 Josep Arnau +5 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Application of an Artificial Neural Network in Reactor Thermohydraulic Problem: Prediction of Critical Heat Flux [PDF]
, 2002 Guanghui Su +3 more
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source