Results 121 to 130 of about 50,351 (318)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2013 In mixed-criticality systems, applications with different levels of criticality are integrated on the same computational platform. Without a proper isolation of the different applications of such a mixed-criticality system certification gets ...
Cilku, Bekim, Puschner, Peter
core
Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression
, 2018 The progression of Alzheimer's Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition?
Jiang, Lili +7 more
core +1 more source
Frontiers in CommunicationThe world has been experiencing huge upheavals since the COVID-19 crises. Conflicts caused by opposing ideologies, economic-political agendas and realities are rampant within or across borders.
Jun Peng, Fred Dervin
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Results of TRIPOLI-4 version 10 on the TRIPOLI Criticality Validation Suite, Part 1,thermal spectra
, 2017 International audienceThis paper presents the results of the latest version of TRIPOLI-4 [1] on its criticality validation suite, part I dedicated to thermal spectra.
Hugot, Fx. +12 more
core
Chromosome Aberration Analysis in Persons Exposed to Low-level Radiation from the JCO Criticality Accident in Tokai-mura [PDF]
, 2001 Chromosome aberrations were studied in peripheral blood lymphocytes of 43 persons who were exposed to low-level radiation of mixed neutrons and γ-rays resulting from the JCO criticality accident.
Sasaki, Masao S. +4 more
core
An analysis of the Spanish high capacity road network criticality
, 2018 The analysis of complex networks has been carried out in different fields using an ample variety of method and concepts. Recently, in the general literature of regional economics, the concepts of resilience, connectivity, vulnerability and criticality ...
Moya Gómez, Borja +10 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source