Results 131 to 140 of about 22,169,646 (299)

Coupled Criticality Analysis of Inflation and Unemployment. [PDF]

open access: yesEntropy (Basel), 2020
Koohi Lai Z   +4 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Criticality dispersion in swarms to optimize n-tuples

open access: yes, 2008
Among numerous pattern recognition methods the neural network approach has been the subject of much research due to its ability to learn from a given collection of representative examples.
Azhar, H., Deravi, F., Dimond, K.
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

The NEA’s working party on nuclear criticality safety: tackling global challenges through international cooperation

open access: yes
Criticality-safety, like much of the nuclear industry, is under pressure to continuously optimise its practices to achieve holistic safety in all facets of energy production, while operating within a context of increased regulatory and societal ...
Martin, Julie-Fiona (author)   +3 more
core   +1 more source

Energy-Efficient Mixed-Criticality Multicore Systems

open access: yesIEEE Access
Balancing energy efficiency with stringent timing guarantees in real-time mixed-criticality systems (MCS) is a key challenge, especially in multicore architectures.
Fayyaz Ali   +6 more
doaj   +1 more source

Uncertainty Analysis in Nuclear Criticality Safety Computations

open access: yes, 2010
Uncertainty analysis is imperative for criticality risk assessments when using computational methods to predict the multiplication factor (keff) for fissionable material systems.
Qi Ao
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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