Results 111 to 120 of about 149,687 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Using Failure Mode, Effect and Criticality Analysis to Improve Safety in the COVID Mass Vaccination Campaign. [PDF]

Vaccines (Basel), 2021
Buja A, Manfredi M, De Luca G, Zampieri C, Zanovello S, Perkovic D, Scotton F, Minnicelli A, De Polo A, Cristofori V, Biasi L, Baldovin T, Bertoncello C, Cocchio S, Baldo V.   +14 more
europepmc   +1 more source

ERP project’s internal stakeholder network and how it influences the project’s outcome [PDF]

So far little effort has been put into researching the importance of internal ERP project stakeholders’ mutual interactions, realizing the project’s complexity, influence on the whole organization, and high risk for a useful final outcome.
Jääskeläinen, Kristian, Pau, Louis-François   +1 more
core   +1 more source

Chiral tricritical point: a new universality class in Dirac systems

, 2018
Tricriticality, as a sister of criticality, is a fundamental and absorbing issue in condensed matter physics. It has been verified that the bosonic Wilson-Fisher universality class can be changed by gapless fermionic modes at criticality.
Jian, Shao-Kai, Yao, Hong, Yin, Shuai
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Finite-size scaling as a tool in the search for the QCD critical point in heavy ion data

, 2011
Given the short lifetime and the reduced volume of the quark-gluon plasma (QGP) formed in high-energy heavy ion collisions, a possible critical endpoint (CEP) will be blurred in a region and the effects from criticality severely smoothened. Nevertheless,
Fraga, Eduardo S., Palhares, Leticia F., Sorensen, Paul   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Component-Based Mixed-Criticality Real-Time Scheduling on a Single Processor System

IEEE Access
This paper focuses on a two-level hierarchical system with dual-criticality components scheduled on a single processor. To address the independent scheduling of mixed-criticality (MC) components using fixed-priority (FP) servers, we introduce the mixed ...
Dandi Ma
doaj   +1 more source

Risk Analysis by Failure Modes, Effects and Criticality Analysis and Biosafety Management During Collective Air Medical Evacuation of Critically Ill Coronavirus Disease 2019 Patients. [PDF]

Air Med J, 2022
Koch L, Nespoulous O, Turc J, Linard C, Martigne P, Beaussac M, Murris S, Ferraris O, Grandadam M, Frenois-Veyrat G, Lopes AA, Boutonnet M, Biot F.   +12 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source