Results 91 to 100 of about 278,381 (298)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The influence of patients infected with H1N1 influenza A virus on acute kidney injury

Linchuang shenzangbing zazhi, 2017
Objective To retrospectively review the clinical characteristics of severe and critically ill patients infected with 2009 pandemic influenza A(H1N1) virus,and analyze the factors associated with acute kidney injury(AKI) in HlNl-infected patients.Methods ...
LI Rui Ying-xin, LI Ying-xin
doaj  

Population pharmacokinetics of intravenous daptomycin in critically ill patients: implications for selection of dosage regimens

Frontiers in Pharmacology
Daptomycin is gaining prominence for the treatment of methicillin-resistant Staphylococcus aureus infections. However, the dosage selection for daptomycin in critically ill patients remains uncertain, especially in Chinese patients.
Jianhua Wu, Xiangyi Zheng, Liu Zhang, Jiajun Wang, Yifei Lv, Yujie Xi, Dongfang Wu   +6 more
doaj   +1 more source

Review: hypercapnia and the critically ill [PDF]

, 1999
Jonathan Ball
openalex   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Risk factors for Candida colonization/infection in non-neutropenic medical critically ill patients [PDF]

, 2001
Joan M. Nolla, Carlos F. Mendes de Leon, R. Jordà, MA León, MJ Pontes, María Isabel Morales‐Casado   +5 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians

BMJ Open
Objectives To assess whether emergency physicians prescribe morphine differently for patients with or without sickle cell disease (SCD). Given the difficulty of comparing strictly homogeneous patients in real clinical settings, we used a standardised ...
Francois-Xavier Ageron, Florence Dupriez, Gregory Yates, Fabien Coisy, Xavier Bobbia, Alexandre Simon, Céline Occelli, Lorie N’Diaye, Anne-Laure Feral-Pierssens   +8 more
doaj   +1 more source

Colistin Use in Critically Ill Patients: Response [PDF]

, 2011
Roberto Imberti, Giorgio Antonio Iotti, Maria Cusato, Mario Regazzi   +3 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source