Results 81 to 90 of about 610,492 (311)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The Superman as Master Narrative in Wole Soyinka’s

open access: yesSAGE Open, 2015
Wole Soyinka’s Season of Anomy is regarded by some as one of the masterpieces of African literature, but it presents challenges in reading, leading others, among them literary critics, to pronounce it a failure.
Amechi N. Akwanya
doaj   +1 more source

Freedom within Nature [PDF]

open access: yes, 2013
In drawing out the relationship between German idealism and critical theory on the question of reason’s autonomy I will concentrate on Adorno’s criticisms of transcendental idealism as it is the most sustained and detailed discussion within the critical ...
O'Connor, Brian
core  

Logic in the tradition of Prabhacandra [PDF]

open access: yes, 2014
The characterization of truth-preserving arguments is a core issue in India and received the detailed attention of philosophers. This chapter presents Prabhācandra’s theory of inference from the eleventh century, stressing its uniqueness and detailed ...
Gorisse, Marie-Hélène
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Revisiting Tagore’s Visit to China: Nation, Tradition, and Modernity in China and India in the Early Twentieth Century

open access: yesThe ASIANetwork Exchange: A Journal for Asian Studies in the Liberal Arts, 2011
This paper aims to discuss the historical background of Rabindranath Tagore’s visit to China in 1924, which proved to be a failure because of harsh criticism from the Chinese side.
Van Symons
doaj   +2 more sources

Hamka, Social Criticism and The Practices of Polygamy in Minangkabau

open access: yesAl-Albab, 2020
The character and style of a text describes and reflects the cultural structure and nature of the author’s mind. This work attempts to describe social criticism and the interpretation of Hamka—the eminent Indonesian exegete—in the Al-Azhar (a fairly ...
Saifuddin Herlambang
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

A new “Romen” Empire : Toni Morrison's love and the classics [PDF]

open access: yes, 2007
An important but little-studied feature of Toni Morrison's novels is their ambivalent relationship with classical tradition. Morrison was a classics minor while at Howard University, and her deployment of the cultural practices of ancient Greece and Rome
Roynon, Tessa Kate
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

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