Results 121 to 130 of about 571,246 (252)

Jean-Marc Durand-Gasselin, La Théorie critique

open access: yes
Professeur de philosophie en khâgne dans un lycée d’Orléans, l’auteur a déjà publié de nombreux ouvrages sur l’Ecole de Francfort, Jürgen Habermas et Walter Benjamin.
Frangne, Pierre-Henry
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The sentinel node concept: A critique of the critique

open access: yesThe Breast, 2006
ee front matter & 2006 Elsevier Ltd. All rights reserv reast.2006.07.005 nal article: 10.1016/j.breast.2006.07.003 le was originally published in issue 15/5, reast.2006.07.003. ess: codyh@mskcc.org. Since Morton’s pioneering report in 1992, sentinel lymph node (SLN) biopsy has entered medical practice with astonishing rapidity, and has largely replaced
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Une rentrée critique ...

open access: yes, 2018
Le 27 Septembre nous nous retrouverons enfin dans la salle des Actes pour la première séance d'Actualité Critique 2018/2019 !Pour ouvrir cette année de travail critique, nous chercherons, à quelques voix, à interroger ce qu'on peut entendre par ...
micol
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Critique d’art et médias

open access: yes, 2016
Publication résultant d'un séminaire de recherche de master 2 en partenariat avec les Archives de la critique d'artInternational ...
Boulouch, Nathalie   +1 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Wittgenstein Goes to Frankfurt (and Finds Something Useful to Say)

open access: yesNordic Wittgenstein Review, 2018
This article aims to shed light on some core challenges of liberating social criticism. Its centerpiece is an intuitively attractive account of the nature and difficulty of critical social thought that nevertheless goes missing in many philosophical ...
Alice Crary
doaj  

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