Results 21 to 30 of about 238,653 (237)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Adoption of CRM: cross-cultural impact, a literature review [PDF]

, 2004
In a competitive world there is a need for companies to maximise all their resources. One of the resources that is often overlooked is that of existing customer base.
Ali, M, Alshawi, S
core  

Intention to use mobile customer relationship management systems [PDF]

, 2014
© Emerald Group Publishing Limited. Purpose - The purpose of this paper is to investigate the behavioral intentions of business-to-business (B2B) sales managers to use mobile customer relationship management (CRM) systems in the course of their day-to ...
Jayawardhena, Chanaka, Karjaluoto, Heikki, Pirttiniemi, Janne, Töllinen, Aarne   +3 more
core   +1 more source

Chemoselective Sequential Polymerization: An Approach Toward Mixed Plastic Waste Recycling

Advanced Functional Materials, EarlyView.
Inspired by biological protein metabolism, this study demonstrates the closed‐loop recycling of mixed synthetic polymers via ring‐closing depolymerization followed by a chemoselective sequential polymerizations process. The approach recovers pure polymers from mixed feedstocks, even in multilayer formats, highlighting a promising strategy to overcome a
Gadi Slor, Youwei Ma, Hyunwoo Park, Tae‐Lim Choi, Damien Guironnet, Francesco Stellacci   +5 more
wiley   +1 more source

Rapid, systematic updating of movement by accumulated decision evidence

Nature Communications
Acting in the natural world requires not only deciding among multiple options but also converting decisions into motor commands. How the dynamics of decision formation influence the fine kinematics of response movement remains, however, poorly understood.
Manuel Molano-Mazón, Alexandre Garcia-Duran, Jordi Pastor-Ciurana, Lluís Hernández-Navarro, Lejla Bektic, Debora Lombardo, Jaime de la Rocha, Alexandre Hyafil   +7 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Computational Analysis of Cross-Flow Heat Exchangers: Effect of Fin Geometry on Thermal and Hydraulic Performance

Journal of Mechanical Engineering
A numerical study using ANSYS Fluent 18.1 software was conducted to examine the fluid flow and heat transfer characteristics in a cross-flow heat exchanger equipped with rectangular, hexagonal, and semi-elliptical finned tubes. Simulations were performed
Bouhabel Bourhane, Abdelfatah Marni sandid, Zouhair Aouissi, Salim Eutamene, Hamza Benhacine, Yazid Ait Ferhat   +5 more
doaj   +1 more source

Customer relationship management as business strategy appliance: Theoretical and practical dimensions

Journal of Business Economics and Management, 2007
The main purpose of this article is to provide an integral and managerially useful view of customer relationship management (CRM) as business strategy. The key objectives are: to analyze CRM origins, development and changes that have occurred over time ...
Rima Tamošiūnienė, Regina Jasilionienė   +1 more
doaj   +1 more source

The prognostic significance of the circumferential resection margin in esophageal squamous cell carcinoma patients without neoadjuvant treatment

BMC Cancer, 2022
Background Circumferential resection margin (CRM) is very important in esophageal cancer, but its diagnostic criteria has not been unified. The College of American Pathologists (CAP) and the Royal College of Pathologists (RCP) provide two different ...
Zhaoyang Yang, Hua Lin, Zhen Wang, Lulu Rong, Xuchen Zhang, Lin Wang, Jianjun Qin, Xuemin Xue, Yin Li, Liyan Xue   +9 more
doaj   +1 more source