Results 111 to 120 of about 4,909,303 (275)

Immunotherapy of Crohn′s disease

Mediators of Inflammation, 1998
Although the initiating events of Crohn′s disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn′s disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this understanding, there has been a shift in
van Montfrans, C., Camoglio, L., van Deventer, S.J.H.   +2 more
openaire   +6 more sources

Radiologic, Histologic and Scanning Electron Microscopic Characterization of the Peritoneal Reflection in Crohn's Disease

Clinical Anatomy, EarlyView.
ABSTRACT The peritoneal reflection bridges visceral and parietal peritoneum and lacks adjoining or underlying organs. As such it provides an opportunity to perform a focussed examination of the peritoneum in Crohn's disease. The aim of this study was to exploit this anatomical property and conduct a multilayered, focussed examination of the peritoneal ...
L. Walsh, D. Walsh, C. P. Dunne, P. Dockery, J. C. Coffey   +4 more
wiley   +1 more source

Granulomatous Cheilitis and Crohn's Disease

Canadian Journal of Gastroenterology, 2001
Granulomatous cheilitis is characterized by recurrent swelling of the labial tissues and granulomatous histology. Granulomatous cheilitis has been recognized as an early manifestation of Crohn's disease.
Ishfaq Ahmad, David Owens
doaj   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.

, 2020
This article is the second in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease.
Kucharzik, Torsten, Warusavitarne, Janindra, Sabino, Joao, Bager, Palle, Vavricka, Stephan, Verstockt, Bram, Bossuyt, Peter, Gomollon, Fernando, El-Hussuna, Alaa, Adamina, Michel, Myrelid, Pär, Uzzan, Mathieu, Bachmann, Oliver, Stassen, Laurents, Gingert, Christian, Juillerat, Pascal, Bokemeyer, Bernd, Armuzzi, Alessandro, Torres, Joana, Katsanos, Konstantinos, Savarino, Edoardo, Furfaro, Federica, Biancone, Livia, Raine, Tim, Lorenzo, Marien González, Fiorino, Gionata, Lytras, Theodore, Magro, Fernando, Pellino, Gianluca, Ellul, Pierre, Gordon, Hannah, Hlavaty, Tibor, Kopylov, Uri, Zmora, Oded, Frei-Lanter, Cornelia, Bonovas, Stefanos, Rosa, Isadora, Burisch, Johan, Doherty, Glen, Marshall, John Kenneth, Spinelli, Antonino, Krustins, Eduards, Collins, Paul, Gionchetti, Paolo, Gisbert, Javier P, Maaser, Christian   +45 more
core   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Anal and rectal cancer in Crohn's disease

, 2003
Several epidemiological studies have been published regarding the risk of Crohn's disease- associated colorectal cancer. The findings are, however, contradictory and it has been particularly difficult to obtain indisputable information on the incidence ...
Myrelid, Pär,, Sjödahl, Rune,, Söderholm, Johan D,   +2 more
core   +1 more source

Intestinal Epithelial Memory: From Inflammatory Imprinting to Metabolite‐Shaped Immune Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Intestinal epithelial cells are rapidly renewing barrier cells that maintain compartmentalization between the luminal environment and the mucosal immune system through epithelial transport, antimicrobial defense, secretory programs, and cytokine‐mediated communication.
Wenjing Yang, Tianming Yu, Yingzi Cong
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis

Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.
Nero, Neil, Fulmer, Clifton,, Holubar, Stefan D.,, Nero, Neil,, Yuan, Yuhong, Hart, Ailsa, Regueiro, Miguel, Bruining, David H, Bemelman, Willem,, Feagan, Brian G, Singh, Siddharth,, Armuzzi, Alessandro,, Ahuja, Vineet, Solitano, Virginia,, Narula, Neeraj, Leong, Rupert W, Halfvarson, Jonas, Solitano, Virginia, Rieder, Florian, Raine, Tim,, Spinelli, Antonino,, Jairath, Vipul, Parker, Claire E.,, Sparrow, Miles P.,, Deepak, Parakkal, Panés, Julian, Ma, Christopher,, Bruining, David H.,, McCurdy, Jeffrey D, Dotan, Iris,, Hart, Ailsa,, McCurdy, Jeffrey D.,, Raine, Tim, Armuzzi, Alessandro, Yadete, Tesfaye,, Fulmer, Clifton, Abushamma, Suha, Falloon, Katherine, Van Koughnett, Julie Ann, Sparrow, Miles P, Yuan, Yuhong,, Abushamma, Suha,, Parker, Claire E, Panés, Julian,, Leong, Rupert W.,, Bemelman, Willem, Ahuja, Vineet,, Dotan, Iris, Singh, Siddharth, Abreu, Maria T.,, Rieder, Florian,, Yadete, Tesfaye, Magro, Fernando, Rogler, Gerhard,, Van Koughnett, Julie Ann,, Jairath, Vipul,, Dignass, Axel, Ma, Christopher, Halfvarson, Jonas,, Rogler, Gerhard, Abreu, Maria T, Deepak, Parakkal,, Narula, Neeraj,, Vuyyuru, Sudheer K.,, Holubar, Stefan D, Vuyyuru, Sudheer K, Dignass, Axel,, Regueiro, Miguel,, Falloon, Katherine,, Feagan, Brian G.,, Magro, Fernando,, Spinelli, Antonino   +71 more
core   +1 more source