Results 111 to 120 of about 10,538,494 (333)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Long-term safety and efficacy of adalimumab in Japanese patients with moderate to severe Crohn's disease

, 2014
Background and aimsAdalimumab has been shown to be effective and well tolerated in patients with Crohn's disease. This analysis reports the results of a cohort of Japanese patients with moderate to severe Crohn's disease who were evaluated for up to ...
Thakkar, Roopal, Mostafa, Nael M., Arora, Vipin, Chao, Jingdong, Watanabe, Mamoru, Camez, Anne, Thakkar, Roshni, Hibi, Toshifumi, Petersson, Joel   +8 more
core   +1 more source

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

Journal of Immunology, 1996
In this study, we investigate whether human inflammatory bowel disease (IBD) (ulcerative colitis and Crohn's disease) is associated with altered lymphokine secretion profiles, as recently found in various animal models of chronic intestinal inflammation.
I. Fuss, M. Neurath, M. Neurath, M. Boirivant, J. Klein, C. Motte, S. Strong, Claudio Fiocchi, Claudio Fiocchi, W. Strober   +9 more
semanticscholar   +1 more source

Radiologic, Histologic and Scanning Electron Microscopic Characterization of the Peritoneal Reflection in Crohn's Disease

Clinical Anatomy, EarlyView.
ABSTRACT The peritoneal reflection bridges visceral and parietal peritoneum and lacks adjoining or underlying organs. As such it provides an opportunity to perform a focussed examination of the peritoneum in Crohn's disease. The aim of this study was to exploit this anatomical property and conduct a multilayered, focussed examination of the peritoneal ...
L. Walsh, D. Walsh, C. P. Dunne, P. Dockery, J. C. Coffey   +4 more
wiley   +1 more source

Anticipation in an Indo-Canadian Family with Crohn's Disease

Canadian Journal of Gastroenterology, 2001
Genetic anticipation, associated elsewhere with monogenic neurological disorders, has been hypothesized to be present in familial forms of Crohn's disease. Usually, with studies of parent-child pairs, the parent who is initially diagnosed is older at the
Hugh J Freeman, Noel B Hershfield
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Crohn’s Disease: a Role of Gut Microbiota and Nod2 Gene Polymorphisms in Disease Pathogenesis

Acta Medica, 2014
Crohn’s disease is a chronic immune-mediated intestinal inflammation targeted against a yet incompletely defined subset of commensal gut microbiota and occurs on the background of a genetic predisposition under the influence of environmental factors ...
Lucia Hrnčířová, Jan Krejsek, Igor Šplíchal, Tomáš Hrnčíř   +3 more
doaj   +1 more source

Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study

The Lancet, 2017
Summary Background Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn’s disease.
S. Kugathasan, L. Denson, T. Walters, Mi‐Ok Kim, U. Marigorta, M. Schirmer, K. Mondal, Chunyan Liu, A. Griffiths, J. Noe, W. Crandall, S. Snapper, S. Rabizadeh, J. Rosh, J. Shapiro, S. Guthery, D. Mack, R. Kellermayer, M. Kappelman, S. Steiner, Dedrick E. Moulton, D. Keljo, Stanley Cohen, M. Oliva-Hemker, M. Heyman, A. Otley, S. Baker, Jonathan Evans, B. Kirschner, Ashish S. Patel, D. Ziring, B. Trapnell, F. Sylvester, Michael C. Stephens, R. Baldassano, J. Markowitz, Judy H. Cho, R. Xavier, C. Huttenhower, B. Aronow, G. Gibson, J. Hyams, M. Dubinsky   +42 more
semanticscholar   +1 more source

Utility of serological markers in inflammatory bowel diseases: Gadget or magic?

, 2007
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Papp, Mária, Lakatos, Péter László, Norman, G. L., Altorjay, István   +3 more
core  

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source