Results 141 to 150 of about 10,512,482 (403)

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Adenocarcinoma of the small intestine arising in crohn's disease: Demonstration of a tumor‐associated antigen in invasive and intraepithelial components [PDF]

, 1975
Robert D. Newman, Sidney Bennett, Robert Pascal   +2 more
openalex   +1 more source

Radiologic, Histologic and Scanning Electron Microscopic Characterization of the Peritoneal Reflection in Crohn's Disease

Clinical Anatomy, EarlyView.
ABSTRACT The peritoneal reflection bridges visceral and parietal peritoneum and lacks adjoining or underlying organs. As such it provides an opportunity to perform a focussed examination of the peritoneum in Crohn's disease. The aim of this study was to exploit this anatomical property and conduct a multilayered, focussed examination of the peritoneal ...
L. Walsh, D. Walsh, C. P. Dunne, P. Dockery, J. C. Coffey   +4 more
wiley   +1 more source

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. [PDF]

, 2019
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular,
Ajami, Nadim J, Ananthakrishnan, Ashwin N, Andrews, Elizabeth, Arze, Cesar, Avila-Pacheco, Julian, Bonham, Kevin S, Braun, Jonathan, Brislawn, Colin J, Casero, David, Clish, Clary B, Courtney, Holly, Denson, Lee A, Franzosa, Eric A, Gonzalez, Antonio, Graeber, Thomas G, Hall, A Brantley, Huttenhower, Curtis, IBDMDB Investigators, Jansson, Janet K, Knight, Rob, Kugathasan, Subra, Lake, Kathleen, Landers, Carol J, Lloyd-Price, Jason, Mallick, Himel, McGovern, Dermot PB, Petrosino, Joseph F, Plichta, Damian R, Poon, Tiffany W, Prasad, Mahadev, Rahnavard, Gholamali, Sauk, Jenny, Schirmer, Melanie, Shungin, Dmitry, Stappenbeck, Thaddeus S, Vlamakis, Hera, Vázquez-Baeza, Yoshiki, White, Richard A, Winter, Harland S, Xavier, Ramnik J   +39 more
core  

The changing face of treatment for Crohn's disease [PDF]

, 2006
Séverine Vermeire, P. Rutgeerts
openalex   +1 more source

Intraosseous sarcoidosis imitating peri‐implantitis: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Sarcoidosis is a multisystem granulomatous disorder of unknown cause, typically affecting the lungs and lymph nodes, but it can also involve the eyes, skin, heart, bones, and other organs. The exact cause is unclear, but genetic factors and environmental triggers like infections, chemicals, or dust may play a role.
Magdalena Orlowska, David S. Gottlieb, Kenneth S. Kornman   +2 more
wiley   +1 more source

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. [PDF]

, 2009
Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data ...
Abraham, Clara, Achkar, Jean-Paul, Annese, Vito, Barmada, M Michael, Bayless, Theodore M, Bossa, Fabrizio, Brant, Steven R, Cho, Judy H, Daly, Mark J, Duerr, Richard H, Goyette, Philippe, Gregersen, Peter K, Griffiths, Anne M, Ippoliti, Andrew F, Kistner, Emily O, Klei, Lambertus, Lahaie, Raymond G, Latiano, Anna, Lee, Annette T, McGovern, Dermot PB, Paré, Pierre, Proctor, Deborah D, Regueiro, Miguel D, Rioux, John D, Roeder, Kathryn, Rotter, Jerome I, Schumm, L Philip, Scott, Regan, Silverberg, Mark S, Steinhart, A Hillary, Targan, Stephan R, Taylor, Kent D, Wu, Jing, Xu, Wei   +33 more
core  

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.

Gastroenterology, 1976
W. Best, J. Becktel, J. Singleton, F. Kern   +3 more
semanticscholar   +1 more source