Results 271 to 280 of about 97,874 (310)

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

Small Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz, Nima Pourafzal, Audrey T. Zhu, Zhongyuan Guo, Ronnie H. Fang, Liangfang Zhang   +5 more
wiley   +1 more source

An agent transmitting Crohn's disease. [PDF]

Canadian Medical Association journal, 1971
openaire   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Volumetric Changes in Perianal Fistulizing Crohn's Disease Measured by Magnetic Resonance Is Feasible and Could Be a Potential Biomarker to Predict Clinical Outcomes

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aim Changes in 3D volumetry of perianal fistulas in patients with Crohn's disease (CD) measured by MRI could be an imaging biomarker of interest. The objective of the study was to determine the value of volumetric changes in CD perianal fistulas after medical treatment to predict outcomes.
Berta Caballol, Ingrid Ordás, Carolina Saavedra, Julia Saidman, Maria Carmen Masamunt, Marta Gallego, Rebeca Barastegui, Agnès Fernández‐Clotet, Alex Menys, Julian Panés, Elena Ricart, Jordi Rimola   +11 more
wiley   +1 more source

Endoscopic Techniques for Colorectal Neoplasia Surveillance in Inflammatory Bowel Disease: A Systematic Review and Network Meta‐Analysis

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims Dye‐based chromoendoscopy (DCE) has been the preferred method for colonoscopy surveillance in patients with inflammatory bowel disease (IBD). However, with advances in endoscopy, virtual chromoendoscopy (VCE) techniques have emerged.
Chih‐Wen Huang, Hsu‐Heng Yen, Yang‐Yuan Chen   +2 more
wiley   +1 more source

Faecalibacterium Diversity in the Gut Microbiome of Crohn's Disease Patients

United European Gastroenterology Journal, EarlyView.
ABSTRACT Faecalibacterium has recently garnered attention for its potential health implications. To better understand its role, we developed and assessed real‐time PCR assays for detecting and quantifying various Faecalibacterium species in human stool samples from both healthy individuals and Crohn's disease patients, either in flare or remission. The
Paul Mclellan, Sandrine Auger, Marie Therese Goudiaby, Loic Brot, Nicolas Benech, Jean Pierre Grill, Anne Bourrier, Denis Mariat, Camille Mayeur, Muriel Thomas, Véronique Robert, Julien Kirchgesner, Laurent Beaugerie, Harry Sokol, Philippe Langella, Philippe Seksik, Jean Marc Chatel   +16 more
wiley   +1 more source

Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research

United European Gastroenterology Journal, EarlyView.
ABSTRACT Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered ...
Andreas Münch, Celia Escudero‐Hernández   +1 more
wiley   +1 more source

Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease

United European Gastroenterology Journal, EarlyView.
ABSTRACT Intestinal stricture remains one of the most challenging complications in Crohn's disease, and its underlying mechanisms are poorly understood. Accumulating evidence suggests that gut microbiota is significantly altered in stenotic intestines and may play a key role in the development of fibrogenesis in Crohn's disease.
Caiguang Liu, Rongchang Li, Jing Nie, Jinshen He, Zihao Lin, Xiaomin Wu, Jinyu Tan, Zishan Liu, Longyuan Zhou, Xiaozhi Li, Zhirong Zeng, Minhu Chen, Shixian Hu, Yijun Zhu, Ren Mao   +14 more
wiley   +1 more source

Global Prevalence of Burnout in Gastroenterology and Endoscopy: A Systematic Review and Meta‐Analysis

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Burnout is an increasingly recognised phenomenon that negatively affects physicians' well‐being, patient safety and the sustainability of healthcare systems. In this systematic review and meta‐analysis, we aimed to estimate the global prevalence of burnout in gastroenterology and endoscopy.
Mohamed G. Shiha, Francesca Manza, John Ong, Iago Rodríguez‐Lago, Martina Müller, Reena Sidhu   +5 more
wiley   +1 more source

Dietary Sugar and Sweetened Beverage Intake Increases Inflammatory Bowel Disease Risk: A Systematic Review and Meta‐Analysis

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims The impact of dietary sugar intake on the risk of developing inflammatory bowel disease is unclear, with inconsistent findings across studies. The aim of this systematic review and meta‐analysis was to clarify how sugar consumption contributes to the risk of developing inflammatory bowel disease (IBD) using the most ...
Isha Maniyar, Arpita Jajoo, Gala Godoy Brewer, Preetha Iyengar, Andrew Nguyen, Christina Fasulo, Jacob White, Alyssa Parian, Berkeley N. Limketkai   +8 more
wiley   +1 more source