Results 191 to 200 of about 72,467 (230)
Some of the next articles are maybe not open access.
Medicina Clínica (English Edition), 2018
Crohn's disease is a chronic inflammatory bowel disease of unknown etiology associated with an impaired immune response, with periods of activity and remission. It is characterised by patchy and transmural lesions which can affect the entire gastrointestinal tract, from the mouth to the anus. The most frequent symptoms are abdominal pain and diarrhoea,
Miguel Mínguez Pérez +2 more
+8 more sources
Crohn's disease is a chronic inflammatory bowel disease of unknown etiology associated with an impaired immune response, with periods of activity and remission. It is characterised by patchy and transmural lesions which can affect the entire gastrointestinal tract, from the mouth to the anus. The most frequent symptoms are abdominal pain and diarrhoea,
Miguel Mínguez Pérez +2 more
+8 more sources
The Lancet, 2017
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, with increasing incidence worldwide. Crohn's disease might result from a complex interplay between genetic susceptibility, environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses.
Torres, Joana +3 more
openaire +4 more sources
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, with increasing incidence worldwide. Crohn's disease might result from a complex interplay between genetic susceptibility, environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses.
Torres, Joana +3 more
openaire +4 more sources
Current Problems in Surgery, 1993
The clinical and pathological description of Crohn’s disease (CD) in 1932 described inflammation of the terminal ileum (1). It was not until 1959, 100 yr after Samuel Wilks described ulcerative colitis (UC), that variants of CD were recognized to potentially, or exclusively, involve the colon (2).
Masanori Tanaka +4 more
openaire +3 more sources
The clinical and pathological description of Crohn’s disease (CD) in 1932 described inflammation of the terminal ileum (1). It was not until 1959, 100 yr after Samuel Wilks described ulcerative colitis (UC), that variants of CD were recognized to potentially, or exclusively, involve the colon (2).
Masanori Tanaka +4 more
openaire +3 more sources
CYCLOSPORIN FOR CROHN'S DISEASE
The Lancet, 1984SUMMARYEight patients with active uncomplicated Crohn's disease, who were resistant to or intolerant of conventional treatment, were treated for 6 weeks with oral cyclosporin (mean dose 8.2 mg kg−1 day−1). Seven of the eight patients responded to treatment with cyclosporin by symptomatic improvement, weight gain and a return of serum C‐reactive protein
R. E. Pounder, M. C. Allison
openaire +5 more sources
The dilemma of Crohn's disease
Diseases of the Colon & Rectum, 1977The results of our clinical study, generally supported by the recent literature and a consensus of colorectal surgeons, indicate that an appendectomy can safely be performed in the presence of Crohn's ileitis. When fistulas do occur, they originate in the small bowel and not in the appendiceal stump.
J. Mullen +3 more
openaire +3 more sources
The Lancet, 2002
Crohn's disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and ...
openaire +3 more sources
Crohn's disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and ...
openaire +3 more sources
The Lancet
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract that might lead to progressive bowel damage and disability. The exact cause of Crohn's disease is unknown, but evidence points towards multifactorial events causing dysregulation of the innate immune system in genetically susceptible people.
Dolinger, Michael +2 more
openaire +3 more sources
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract that might lead to progressive bowel damage and disability. The exact cause of Crohn's disease is unknown, but evidence points towards multifactorial events causing dysregulation of the innate immune system in genetically susceptible people.
Dolinger, Michael +2 more
openaire +3 more sources
2015
Crohn’s disease (CD), with ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBD-U), belongs to the group of inflammatory bowel diseases (IBD), that are chronic, idiopathic, and detrimental disorders of the gastrointestinal tract.
Salvatore Cucchiara, Marina Aloi
openaire +2 more sources
Crohn’s disease (CD), with ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBD-U), belongs to the group of inflammatory bowel diseases (IBD), that are chronic, idiopathic, and detrimental disorders of the gastrointestinal tract.
Salvatore Cucchiara, Marina Aloi
openaire +2 more sources
Annals of the New York Academy of Sciences, 2006
Abstract: The immense microbiological load of the gastrointestinal tract poses a daunting challenge for the mucosal immune system: whereas it should tolerate the vast number of commensal bacteria, it should adequately attack pathogenic organisms. Millions of years of co‐evolution have produced an intricate system in which interactions between the ...
Daan W. Hommes +2 more
openaire +5 more sources
Abstract: The immense microbiological load of the gastrointestinal tract poses a daunting challenge for the mucosal immune system: whereas it should tolerate the vast number of commensal bacteria, it should adequately attack pathogenic organisms. Millions of years of co‐evolution have produced an intricate system in which interactions between the ...
Daan W. Hommes +2 more
openaire +5 more sources