Results 291 to 300 of about 61,456 (351)

Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease. [PDF]

Clin Epigenetics
de Ponthaud C, Abdalla S, Belot MP, Shao X, Penna C, Brouquet A, Bougnères P.   +6 more
europepmc   +1 more source

Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
Succinate promotes macrophage to the M1 phenotype in the mouse mononuclear macrophage leukemia cells (Raw264.7 cells) and neonatal mice with NEC. Succinate activates the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) pathway via succinate recepter 1 (SUCNR1), promoting M1 polarization of NEC intestinal macrophages.
Sha Liu, Fang‐Ling Tang, Xiao‐Lin Yan, Xiao‐Chen Liu, Qing Ai, Lu‐Quan Li, Lei Bao   +6 more
wiley   +1 more source

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, EarlyView.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source

A 15‐year population‐based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy

Pediatric Investigation, EarlyView.
Increasing incidence of pediatric inflammatory bowel disease (IBD) and suboptimal vaccination coverage in Apulia, Italy (2009–2023). A total of 1044 incident cases of paediatric IBD were identified in the period 2009–2023 in Apulia, Italy, giving an average annual standardized incidence rate of 12.7/100 000. A significant increase in incidence occurred
Francesca Fortunato, Angelo Campanozzi, Michele Di Toma, Alessandra Marinari, Domenico Martinelli   +4 more
wiley   +1 more source

Correction: Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease. [PDF]

Clin Epigenetics
de Ponthaud C, Abdalla S, Belot MP, Shao X, Penna C, Brouquet A, Bougnères P.   +6 more
europepmc   +1 more source

Longstanding Perianal Ulcers

JEADV Clinical Practice, EarlyView.
Narachai Julanon, Thanaphon Anutraungkool, Sirawich Jessadapattarakul, Vincent Piguet   +3 more
wiley   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis. [PDF]

Ann Surg Open
van der Does de Willebois EML, Bellato V, Duijvestein M, van Dieren S, Danese S, Sileri P, Buskens CJ, Vignali A, Bemelman WA.   +8 more
europepmc   +1 more source

Identification of shared disease marker genes and underlying mechanisms between rheumatoid arthritis and Crohn disease through bioinformatics analysis. [PDF]

Medicine (Baltimore)
Peng P, Shen Y.
europepmc   +1 more source