Results 61 to 70 of about 636,692 (299)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Suitability of different crops and cropping systems for contingency crop planning

INTERNATIONAL JOURNAL OF FORESTRY AND CROP IMPROVEMENT, 2015
The experiment was conducted at the Dry Land Agricultural Research Centre, Vasantrao Naik Marathwada Agricultural University, Parbhani during Kharif and Rabi seasons of 2006-2007 and 2007-2008. Eight different promising cropping systems of important crop of Marathwada region were tested in varied weather condition under rain fed agriculture. At the
R. M. Dheware, A. V. Wakure, R. G. Bhagyawant   +2 more
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Spatial and temporal variation in weather events critical for boreal agriculture: III Frost and winter time fluctuation

Agricultural and Food Science, 2016
In the boreal zone of Europe, differences between the four seasons are considerable. Also, the within-season variation in climatic conditions is substantial.
Pirjo Peltonen-Sainio, Pentti Pirinen, Mikko Laapas, Hanna M. Mäkelä, Hannu Ojanen, Ari Venäläinen   +5 more
doaj   +1 more source

A Systematic Review on Case Studies of Remote-Sensing-Based Flood Crop Loss Assessment

Agriculture, 2020
This article reviews case studies which have used remote sensing data for different aspects of flood crop loss assessment. The review systematically finds a total of 62 empirical case studies from the past three decades.
Md Shahinoor Rahman, Liping Di
doaj   +1 more source

Ozone effects on crops and consideration in crop models

European Journal of Agronomy, 2018
We review current knowledge of the processes by which ozone will cause injury and damage in crop plants. We do this both through an understanding of the limitations to ozone uptake (i.e. ozone being transferred from some height in the atmosphere to the leaf boundary layer and subsequent uptake via the stomata) as well as through the internal plant ...
Emberson, Lisa Dianne, Pleijel, Hakan, Ainsworth, Lisa, Van den Berg, Maurits, Ren, Wei, Osborne, Stephanie Alice, Mills, Gina, Pandey, Divya, Dentener, F., Bueker, Patrick, Ewert, Frank, Koeble, Renate, Van Dingenen, Rita   +12 more
openaire   +4 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

Metabolites, 2020
Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites.
Vimalraj Mani, Seon-Kyeong Lee, Yunsoo Yeo, Bum-Soo Hahn   +3 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source