Results 31 to 40 of about 4,539 (169)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Assessing Crop Water Demand and Deficit for the Growth of Spring Highland Barley in Tibet, China
Journal of Integrative Agriculture, 2013 The aim of this study was to assess the crop water demand and deficit of spring highland barley and discuss suitable irrigation systems for different regions in Tibet, China.
Zhao-fei LIU +3 more
doaj +1 more source
Agriculture, 2022 The solar greenhouse is a common protected structure for crop production when ambient temperatures are low. In the North China Plain (NCP) winter temperatures are very low and an improved solar greenhouse with a lowered soil surface (0.5–1.5 m deep ...
Li Yang +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Remote SensingThe goal of this study is to investigate the usefulness of the relatively new 30 m spatial and 0.67 and RMSE < 0.15). ETc prediction resulted in an MAE ranging between 0.35- and 0.64-mm day−1, an MSE ranging between 0.20- and 0.75-mm day−1 and an MAPD ...
Robert Sabie +4 more
doaj +1 more source
Sensors, 2021 Over recent years, the demand for supplies of freshwater is escalating with the increasing food demand of a fast-growing population. The agriculture sector of Pakistan contributes to 26% of its GDP and employs 43% of the entire labor force.
Huma Zia +4 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Measuring Crop Coefficient For Vineyards
مجلة النهرين للعلوم الهندسية, 2016 In this paper crop coefficient for vineyard was measure from water consumption or crop evapotranspiration in afield of vineyeard located in Travers City, Michigan State/ United State of America. The objectives were to find it varaities with time as plant
Sabah Anwer Dawood Al masraf
doaj