Results 71 to 80 of about 78,085 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cover crop coefficient of variation in relation to cover crop biomass.

, 2019
Coefficient of variation of aboveground cover crop biomass across treatments and study sites plotted against mean cover crop biomass. Pearson correlation coefficients (r) also given with p-values for the following test—H0: r = 0; Ha: r ≠ 0.
A. M. Florence (6459143), L. G. Higley (6459146), C. A. Francis (6459152), R. A. Drijber (6459149), J. L. Lindquist (6459155)   +4 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Crop Water Use and Crop Coefficients of Maize in the Great Plains

Journal of Irrigation and Drainage Engineering, 2018
AbstractMaize water use was measured by water balance in a 6-year field trial in the west-central Great Plains of the United States.
Thomas J. Trout, Kendall C. DeJonge
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Estimating Crop Coefficients Using Remote Sensing-Based Vegetation Index

Remote Sensing, 2013
Crop coefficient (Kc)-based estimation of crop evapotranspiration is one of the most commonly used methods for irrigation water management. However, uncertainties of the generalized dual crop coefficient (Kc) method of the Food and Agricultural ...
Kenneth Hubbard, Baburao Kamble, Ayse Kilic   +2 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Spontaneous gene flow and population structure in wild and cultivated chicory, Cichorium intybus L.

, 2008
Spontaneous gene flow between wild and cultivated chicory, Cichorium intybus L., may have implications for the genetic structure and evolution of populations and varieties.
Hauser, Thure P., Bagger Jørgensen, Rikke, Guadagnuola, R., Scotti, I., Jorgensen, R. B., Wiel, C., Kiær, L. P., I. Scotti, Hauser, T., JORGENSEN R. B., L. P. Kiær, FELBER F, GUIATTI, Denis, Kiær, L., R. Guadagnuolo, Kiaer, L.P., D. Guiatti, N. Syed, M. Vischi, Olivieri, A., KIAER L. P, T. P. Hauser, Kiaer, L. P., van de Wiel, C.C.M., van de Wiel, C., Jorgensen, R.B., SCOTTI I, C. van de Wiel, Flavell, A., F. Felber, Wiel, C. van de, VISCHI, Massimo, Vischi, M., Hauser, T.P., VAN DE VIEL C, Hauser, T. P., Kiær, Lars Pødenphant, SYED N, Guadagnuolo, Roberto, Guiatti, D., Jørgensen, R., OLIVIERI A. M, Scotti, Ivan, GUADAGNUOLO R, R. B. Jørgensen, Jørgensen, R.B., HAUSER T. P, Guadagnuolo, R., A. Flavell, Felber, F., Olivieri, A.M., Jørgensen, R. B., Hauser, Thure Pavlo, Olivieri, A. M., Syed, N., A. M. Olivieri, FLAVELL A, Felber, François, Wiel, C.C.M., van de   +58 more
core   +1 more source

Estimation of Evapotranspiration ETc and Crop Coefficient Kc of Wheat, in south Nile Delta of Egypt Using integrated FAO-56 approach and remote sensing data

Egyptian Journal of Remote Sensing and Space Sciences, 2012
Crop water requirements are represented by the actual crop evapotranspiration. Estimation of crop evapotranspiration (ETc) and crop coefficient using remote-sensing data is essential for planning the irrigation water use in arid and semiarid regions ...
E. Farg, S.M. Arafat, M.S. Abd El-Wahed, A.M. EL-Gindy   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source