Results 101 to 110 of about 156,634 (316)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Concepts, approaches, and avenues for modelling crop health and crop losses [PDF]

, 2017
This article addresses the modelling of crop health and its impact on crop losses, with a special emphasis on plant diseases. Plant disease epidemiological models have many different shapes.
Armando Bergamin Filho, Laetitia Willocquet, Bergamin Filho, Armando, Andrew D. Nelson, Neil McRoberts, Sparks, Adam, Nelson, Andrew D., Paul D. Esker, Savary, Serge, Castilla, Nancy, Rossi, Vitorrio, Djurle, Annika, Karen Garrett, Garrett, Karen A., Yuen, Jonathan, Nelson, Andrew D.; id_orcid, Sparks, Adam H., Tito Caffi, Nelson, Andrew, Filho, Armamando Bergamin, Amorim, Lilian, Rossi, Vittorio, Esker, Paul D., Esker, Paul, Willocquet, Laetitia, Caffi, Tito, Adam Sparks, Jonathan Yuen, Annika Djurle, Nancy Castilla, Vittorio Rossi, Serge Savary, McRoberts, Neil, Garrett, Karen, Filho, Armando Bergamin, Lilian Amorim   +35 more
core   +1 more source

Effect on yield, nutrient uptake and quality of potato (Solanum tuberosum L.) under integrated nutrient management

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Potato (Solanum tuberosum L.) is a heavy feeder and highly responsive to nutrient input, where the proper quantity and timing of nutrient supply is most critical component in achieving high productivity in potato cultivation. To assess the crop response
S. KARUBAKEE, Bama Shankar RATH, Manoranjan SATAPATHY, Ashok MISHRA   +3 more
doaj   +1 more source

Ground-Based LiDAR Improves Phenotypic Repeatability of Above-Ground Biomass and Crop Growth Rate in Wheat. [PDF]

Plant Phenomics, 2020
Deery DM, Rebetzke GJ, Jimenez-Berni JA, Condon AG, Smith DJ, Bechaz KM, Bovill WD.   +6 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cover crop-based ecological weed management: exploration and optimization

, 2008
Keywords: organic farming, ecologically-based weed management, cover crops, green manure, allelopathy, Secale cereale, Brassica napus, Medicago sativa Cover crop-based ecological weed management: exploration and optimization. In organic farming systems,
Kruidhof, H.M.
core  

Effects of Nitrogen Application at Different Levels by a Sprinkler Fertigation System on Crop Growth and Nitrogen-Use Efficiency of Winter Wheat in the North China Plain

Nitrogen (N) is an essential macronutrient for crop growth; therefore, N deficit can greatly limit crop growth and production. In the North China Plain (NCP), winter wheat (Triticum aestivum L.) is one of the main food crops, and its yield has increased ...
Haijun Liu, Zhuangzhuang Gao, Keke Wang
core   +1 more source

The effect of the previous crop on the growth, nitrogen uptake and yield of winter barley intended for malting

, 1993
Winter barley which received a range of nitrogen rates, was grown at Rothamsted as a test crop after winter oats, winter barley, winter beans, oilseed rape or potatoes, to compare the effects of previous crop on growth and N uptake.
Dudley G Christian, Norman L Carreck, Carreck, N. L., Christian, D. G.   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source