Results 81 to 90 of about 10,148,502 (254)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Managing Crop Production Risk with Crop Index Insurance Products [PDF]

Index crop insurance products can eliminate the asymmetric information problem inherent in farm-level multiple peril crop insurance. Purchasers of index insurance products are, however, exposed to basis risk.
Hoogenboom, Gerrit, Yu, Yingzhuo, Deng, Xiaohui, Barnett, Barry J.   +3 more
core  

Application of DSSAT crop model for wheat crop growth simulation in some wheat growing districts of northern India [PDF]

, 2017
Process based Crop growth simulation models are being used as a potential decision support tool for informed decision making by policy makers and researchers.
KV Ramana, et al., Bhabhana Sahay, Anima Biswal   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

EVALUATION OF CROP INSURANCE PREMIUM RATES FOR GEORGIA AND SOUTH CAROLINA PEACHES [PDF]

We estimate actuarially fair premium rates for yield insurance for Georgia and South Carolina peaches for comparison to the premium rates established by the Risk Management Agency (RMA) for the 1999 crop.
Rathwell, P. James, Kahl, Kandice H., Miller, Stephen E.   +2 more
core  

Crop and Weather Update - First Week of October [PDF]

, 2009
ISU Extension climatologist Elwynn Taylor, economist Dan Otto, and soybean agronomist Palle Pedersen are guests this week for the crop and weather ...
Integrated Crop Management News
core  

Effects of Nitrogen Fertilization on Dark-Respiration and Growth Efficiency of Field-Grown Rice Plants

Plant Production Science, 2000
The growth efficiency (GE), specific dark-respiration rate (Rs) and crop growth rate (CGR) of rice plants grown in the field with applications of nitrogen fertilizer at 0, 11 and 17 g per m2 were examined every two weeks in 1996 and 1997.
Kuniyuki Saitoh, Toshiyuki Doi, Toshirou Kuroda   +2 more
doaj   +1 more source

Responses of Fourteen Vietnamese Rice (Oryza sativa L.) Cultivars to High Temperatures during Grain Filling Period under Field Conditions

Agronomy, 2017
High temperatures significantly affect rice grain yield and quality. However, little information is known about the response of indica cultivars, especially Vietnamese cultivars, to high temperature.
Tran Loc Thuy, Kuniyiki Saitoh
doaj   +1 more source