Results 61 to 70 of about 156,634 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Whole-crop cereals in dairy production [PDF]

, 2008
The four studies summarised and discussed in this thesis evaluate the use of whole-crop cereal silage (WCCS) for cattle in dairy production. The dry matter (DM) yield, chemical composition, digestibility, feed intake and milk production for WCCS were ...
Wallsten, Johanna
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Trend and Growth Rate Estimation of Principal Crops in Karnataka State in India

International Journal of Plant & Soil Science, 2022
The study undertaken to analyse the growth rate performance of area, production, productivity of selected  crops in Karnataka  from year 1997 to 2019. At state level, it was found that, the productivity of cereals showed positive growth with 1.22 percent. The area under maize increased by 5.30 percent by displacing Jowar, Bajra, minor millets. The rice
Sirisha Tadigiri, R. N. Padaria, R. K. Paul, Naveen P. Singh, Pramod Kumar, Seedari Ujwala Rani   +5 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Potassium deficiency reduces sugar yield in sugar beet through decreased growth of young plants

, 2022
Background Optimum potassium (K) nutrition is essential for high sugar yield and quality of beet crops. Aims We quantified the effect of potassium deficiency on sugar beet dry matter and sugar yield formation during the growing season.
Füllgrabe, Henrik; 1 Plant Nutrition and Crop Physiology, Department of Crop Sciences University of Göttingen Göttingen Germany, Füllgrabe, Henrik, Kreszies, Tino, Claassen, Norbert; 1 Plant Nutrition and Crop Physiology, Department of Crop Sciences University of Göttingen Göttingen Germany, Hilmer, Reinhard; 1 Plant Nutrition and Crop Physiology, Department of Crop Sciences University of Göttingen Göttingen Germany, Claassen, Norbert, Hilmer, Reinhard, Koch, Heinz‐Josef, Dittert, Klaus, Dittert, Klaus; 1 Plant Nutrition and Crop Physiology, Department of Crop Sciences University of Göttingen Göttingen Germany, Koch, Heinz‐Josef; 2 Institute of Sugar Beet Research Göttingen Germany   +10 more
core   +1 more source

Growth analysis and yield evaluation under tillage and weed management practices in maize-wheat cropping system

Environment Conservation Journal, 2023
Integrated weed management strategies combine tillage systems and weed control strategies. Conservation agriculture (CA) and sustainable intensification cropping systems are potential sources of improved growth and overall productivity.
Sachin Kumar, Surinder Singh Rana, Neelam Sharma, Abha Sharma   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Growth Rate of Area, Production and Productivity of Sugarcane Crop in India

, 2020
Abstract— Sugarcane is an important commercial crop of India. It plays a crucial role for overall socio-economic development of farming community. India ranks second in production of sugarcane after Brazil. In India about 4.73-million-hectare land is occupied by sugarcane crop.
Nida Bee, Fazlur Rahman
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source