Results 101 to 110 of about 1,215,985 (267)
, 2023 The CROP Inc. political surveys in the Canadian Opinion Research Archive are focussed primarily on the political attitudes of residents in Quebec. The surveys were conducted on an occasional basis depending on events in the province. The are concentrated,
CROP
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
CROP Political Survey 1992-04B
, 2023 The CROP Inc. political surveys in the Canadian Opinion Research Archive are focussed primarily on the political attitudes of residents in Quebec. The surveys were conducted on an occasional basis depending on events in the province. The are concentrated,
CROP
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Eco-evolutionary agriculture: Host-pathogen dynamics in crop rotations.
PLoS Computational Biology, 2020 Since its origins, thousands of years ago, agriculture has been challenged by the presence of evolving plant pathogens. Temporal rotations of host and non-host crops have helped farmers to control epidemics among other utilities, but further efforts for ...
Maria Bargués-Ribera +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
National weather and crop bulletin.
, 1887 In 1919, no. 37, the Snow and ice bulletin was combined with this and during winter months the title reads: National weather and crop and snow and ice bulletin.Monthly numbers for 1887 have title: Special bulletin for April, May, June, October, November,
Its. Weather-crop bulletin. +3 more
core
CROP Political Survey 2004-06C
, 2023 The CROP Inc. political surveys in the Canadian Opinion Research Archive are focussed primarily on the political attitudes of residents in Quebec. The surveys were conducted on an occasional basis depending on events in the province. The are concentrated,
CROP
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2023 The CROP Inc. political surveys in the Canadian Opinion Research Archive are focussed primarily on the political attitudes of residents in Quebec. The surveys were conducted on an occasional basis depending on events in the province. The are concentrated,
CROP
core +1 more source