Results 41 to 50 of about 3,051,348 (300)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impacts of Climate Change on indirect human exposure to pathogens and chemicals from agriculture [PDF]

, 2008
Objective: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today.
Hardy, Anthony, Levy, Leonard, Richard J. Williams, Boucard, Tatiana, Falloon, Peter D, Peter D. Falloon, Turley, David B, Levy, Leonard S., Gordon Nichols, Wellington, Elizabeth M H, Stone, D, Stone, David, Williams, Richard J., Tatiana Boucard, Boxall, AB, Williams, Richard, Boucard, T, Buelke, Sabine, Parsons, Simon, Boxall, Alistair BA, Wellington, Elizabeth MH, Leonardi, Giovanni, Leonardi, G, Kerry Walsh, Edward Topp, Walsh, Kerry, Boxall, Alistair B. A., Thomas Hutchinson, Parsons, Simon A, Kovats, RS, David Stone, Burgin, Laura, Haygarth, Philip, Wellington, Elizabeth, Parsons, SA, Kovats, R Sari, David B. Turley, Nichols, G, Nichols, Gordon, Falloon, Peter, Haygarth, Philip M, Topp, E, Levy, Leonard S, Haygarth, PM, Anthony Hardy, Hutchinson, T, Leonard S. Levy, Alistair B.A. Boxall, Laura Burgin, Kovats, R. Sari, Giovanni Leonardi, Haygarth, Philip M., Turley, David B., Parsons, Simon A., Beulke, Sabine, Williams, RJ, Wellington, EMH, Elizabeth M.H. Wellington, Beulke, S, Hutchinson, Thomas, Turley, DB, Levy, LS, Potts, L, Falloon, PD, Philip M. Haygarth, Simon A. Parsons, Sabine Beulke, R. Sari Kovats, Boxall, ABA, Boxall, Alistair, Hardy, A, Falloon, Peter D., Wellington, Elizabeth M. H., Potts, Laura, Topp, Edward, Walsh, K, Boxall, Alistair B.A., Boxall, Alistair B A, Kovats, Sari, Turley, David, Burgin, L, Wellington, E. M. H., Laura Potts, Williams, Richard J, Hutchinson, TH   +84 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The biological activities of Citrus species in crop protection

Journal of Agriculture and Food Research
Citrus, a globally cultivated genus, is rich in bioactive compounds like flavonoids and essential oils, known for their health benefits and antimicrobial properties.
Marta Lo Vetere, Valeria Iobbi, Anna Paola Lanteri, Andrea Minuto, Giovanni Minuto, Nunziatina De Tommasi, Angela Bisio   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Applying Chemical Data to Crop Protection Discovery

No journal title, 2022
This is a flash presentation highlighting working with agri-chemical data. It was presented at the “The IUPAC WorldFAIR Chemistry Webinar “What is a chemical? – Applying Chemical Data to Industry Challenges”. The event was held on October 13, 2022, 12-1:30 pm EDT. The recording of the full webinar is available here.
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

TAC Panel on Crop Protection Research: Report

, 1990
Report of the TAC Panel on Crop Protection Research, part of the process of considering ICIPE for support by the CGIAR. It was one of seven such panels created as part of the TAC assessment of non associated centers for support from the CGIAR.
CGIAR Technical Advisory Committee Panel on Crop Protection Research
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source