Results 131 to 140 of about 71,185 (308)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Response of Bacterial Community Structure in the Bulk Soil and Rice Straw Residues under Different Crop Rotation Systems

open access: yesAdvances in Agriculture
This study investigated the effect of upland crop rotation on soil bacterial community in bulk soil and rice straw residues in the alluvial soils. Soil samples and rice straw residues in two crop rotation models including triple rice and rice-upland ...
Tran Van Dung   +4 more
doaj   +1 more source

Household use of crop residues and fuelwood for cooking and newborn birth size in rural Bangladesh. [PDF]

open access: yesOccup Environ Med, 2022
Lee MS   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Measure your crop residue

open access: yes, 1999
By now, many producers have completed a great deal of this year's planting, and that means it is a good time to measure crop residues--the stems and stalks remaining from last year's crop.
Tidman, Michael, Miller, Gerald
core   +1 more source

Environmental Impacts of Diverting Crop Residues to Fuel Use [PDF]

open access: yes, 1997
Shortage of fuel wood has lead many rural people to switch to using agricultural residues as an alternative energy source. However this has not always been met with universal acclaim due to the role of residues as fertilisers.
Clancy, Joy S., Clancy, Joy S.; id_orcid
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Farmers’ Willingness to Grow Switchgrass as a Cellulosic Bioenergy Crop: A Stated Choice Approach

open access: yes
Farmers’ Willingness to Grow Switchgrass as a Cellulosic Bioenergy Crop: A Stated Choice Approach Agriculture’s role as a source of feedstocks in a potential lignocellulosic-based biofuel industry is a critical economic issue.
Williams, Jeffery R.   +2 more
core   +1 more source

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