Results 111 to 120 of about 1,168,431 (343)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Global potential nitrogen recovery from anaerobic digestion of agricultural residues

Environmental Research Letters
Meeting the anticipated 50% increase in global food demand by 2050 requires a crucial reassessment of agricultural practices, particularly in terms of nitrogen fertilizers inputs.
Pietro Marconi, Lorenzo Rosa
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pesticide residues in food : 1992, toxicology evaluations, joint meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues, Rome, 21-30 September 1992. Part 2., Toxicology

, 1993
Sponsored jointly by FAO and WHO with the support of the International Programme on Chemical SafetyWHO/PCS/93.34422 p.Presents detailed evaluations of the available toxicological and other safety data for eighteen pesticides that have the potential to ...
World Health Organization, WHO Expert Group on Pesticide Residues, FAO Panel of Experts on Pesticide Residues in Food and the Environment, International Programme on Chemical Safety   +3 more
core  

Protein-bound veterinary drug residues in food [PDF]

, 1999
End of Project ReportBound residues of veterinary drugs have been recognised as an important aspect of food safety particularly (a) where such residues may persist for long periods after withdrawal of the drug treatment and (b) where the bound residues ...
Cadogan, Aodhmar, Coyle, Tiernan, O'Keeffe, Michael, Horne, Elizabeth   +3 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

ENERGY POTENTIAL FROM AGRICULTURAL RESIDUES IN TEXAS [PDF]

Resource /Energy Economics and Policy,
Patton, William P., Oursbourn, Cecil D., Lacewell, Ronald D., Lepori, Wayne   +3 more
core  

Segmentation and Proportion Extraction of Crop, Crop Residues, and Soil Using Digital Images and Deep Learning

Agriculture
Conservation tillage involves covering the soil surface with crop residues after harvest, typically through reduced or no-tillage practices. This approach increases the soil organic matter, improves the soil structure, prevents erosion, reduces water ...
Guangfu Gao, Shanxin Zhang, Jianing Shen, Kailong Hu, Jia Tian, Yihan Yao, Qingjiu Tian, Yuanyuan Fu, Haikuan Feng, Yang Liu, Jibo Yue   +10 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source