Results 41 to 50 of about 52,175 (307)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Some general principles of crop rotation experiments
, 1986 This review paper deals with some of the general statistical principles of crop rotation experiments. The basic terminology of the subject is defined. Attention is paid to the fundamental design principle that each phase of a rotation should each year be
Preece, D. A.
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Crop yield and water use efficiency in response to long-term diversified crop rotations
Frontiers in Plant Science, 2022 Crop production and water productivity may be impacted by diverse crop rotation and management practices. A field study was conducted from 2017-2020 in the Loess Plateau to evaluate the effects of crop rotation sequences on pre-planting and post-harvest ...
Zhengjun Cui +20 more
doaj +1 more source
Soil Chemical Properties as Affected by Six Crop Rotation Sequences and Four Residue Levels
, 2023 Crop rotations with residue incorporation can be beneficial to the sustainability of agriculture, however as long-term studies are required to determine effects on soil properties, farmers usually don’t practice crop rotations.
Haefele, S. M. +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Agricultural & Environmental Letters, 2016 This work evaluated the level and nature of water-extractable soil organic matter (WEOM) from a 6-yr potato ( L.) crop rotation field experiment. The content of WEOM was higher in continuous potato soils than in the 2-yr and 3-yr crop rotation soils ...
Zhongqi He +5 more
doaj +1 more source
Agronomy, 2022 The key to soil organic matter management is understanding the transformation processes of fresh organic matter to permanent humus that control soil organic carbon dynamics.
Dorota Pikuła, Olga Ciotucha
doaj +1 more source
Tracking nitrogen losses in a greenhouse crop rotation experiment in North China using the EU-Rotate_N simulation model [PDF]
, 2010 Vegetable production in China is associated with high inputs of nitrogen, posing a risk of losses to the environment. Organic matter mineralisation is a considerable source of nitrogen (N) which is hard to quantify.
Chen, Q. (Qing) +4 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source