Results 41 to 50 of about 1,162,674 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Effect of Preceding Crop, Nitrogen Fertilizer and Return of Crop Residue on Growth and Yield of Wheat

پژوهشهای زراعی ایران, 2011
This study was conducted under cold temperate climate condition in Khorasan during 2006-2008 growing season to determine the suitable preceding crop, nitrogen and crop residue management for wheat.
M. Rahimi, B. Rabiei, M. Ramezani, S. Movafegh   +3 more
doaj   +3 more sources

Assimilation and return of nutrient elements by plants in soil and impact of crop residues on soil fertility in short cotton rotations

Растениевъдни науки, 2015
To develop a highly efficient the short cycled rotations which provide conservation and improvement soil fertility, of Silt Loam Calcic Xerosol (FAO, 2003) of Tashkent region and the results of the investigations recommend and inculcate to agricultural ...
Abdulaly Iminov, Fazliddin Namazov, Bakhodir Khalikov   +2 more
doaj  

Quantity and Nature of Water-Extractable Organic Matter from Sandy Loam Soils with Potato Cropping Management

Agricultural & Environmental Letters, 2016
This work evaluated the level and nature of water-extractable soil organic matter (WEOM) from a 6-yr potato ( L.) crop rotation field experiment. The content of WEOM was higher in continuous potato soils than in the 2-yr and 3-yr crop rotation soils ...
Zhongqi He, Mingchu Zhang, Aiqin Zhao, O. Modesto Olanya, Robert P. Larkin, C. Wayne Honeycutt   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Brain physiology during photoperiod-related caste determination in the primitively eusocial wasp Polistes jokahamae

Scientific Reports
Adult females of the primitively eusocial wasp Polistes jokahamae can change caste in response to photoperiod length. Short-day photoperiod females store more lipids but have less developed ovaries for hibernation (becoming gynes), whereas long-day ...
Ken Sasaki, Hideto Yoshimura, Kakeru Yokoi   +2 more
doaj   +1 more source

Unveiling the Effects of Crop Rotation on Cropland Soil pH Mapping: A Remote Sensing-Based Soil Sample Grouping Strategy

Remote Sensing
Crop rotation affects soil pH by disturbing H+ production and consumption within soil–crop systems, primarily through fertilization, irrigation, cropping, and harvest. Studies have shown that crop rotation improves soil organic matter prediction. However,
Yuan Liu, Songchao Chen, Ge Shen, Cheng Chen, Zejiang Cai, Ji Zhu, Xia Zhang, Guofei Shang, Qingbo Zhou, Sonoko Dorothea Bellingrath-Kimura, Qiangyi Yu, Wenbin Wu   +11 more
doaj   +1 more source

Soil Seed Banks and Their Relation to Soil Properties in Hilly Landscapes

Plants, 2023
For the prevention of hilly soils from erosion, a smart selection of crop rotations is very important. The aim of this study was to investigate the influence of different agrophytocenoses on seed numbers in the soil runoff sediments and soil seed banks ...
Regina Skuodienė, Vilija Matyžiūtė, Gintaras Šiaudinis   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Some general principles of crop rotation experiments

, 1986
This review paper deals with some of the general statistical principles of crop rotation experiments. The basic terminology of the subject is defined. Attention is paid to the fundamental design principle that each phase of a rotation should each year be
Preece, D. A.
core   +1 more source