Results 61 to 70 of about 239,815 (310)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Apstract: Applied Studies in Agribusiness and Commerce, 2019 Nowadays, nearly 90% of global water consumption is caused by irrigation activities, and more than 40% of the crops are produced under irrigated conditions.
Mohannad Alobid, István Szűcs
doaj +1 more source
Crop water requirement at different growing stages of pineapple production in BRIS soil [PDF]
, 2010 The BRIS (Beach Ridges Interspersed with Swales) soils are the sandy marine deposits at the east coast of Peninsular Malaysia. The area is less suitable for usual field crops.
Abd. Aziz, Z. +4 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
EFFECT OF GROUND WATERTABLE ONIRRIGATION SCHEDULING MODEL
Tikrit Journal of Engineering Sciences, 2005 An irrigation scheduling model was developed based on daily soil water balance which takes into account the effect of water table on irrigation water requirement for wheat crop at Mosul area for eleven years.
Eman H. Sheet, Entesar M. Ghazal
doaj +3 more sources
Teknologi Irigasi Tetes “Ro Drip” Untuk Budidaya Tanaman Sayuran Di Lahan Kering Dataran Rendah [PDF]
, 2006 Key success of cultivation vegetable crop in lowland is gift irrigate and the manure which enough. The other side of dissimilar lowland of generally owning water source limited and its land ground less be fertile, this represent constraint. Technological
Kasiran, K. (Kasiran)
core
Optimal irrigation water allocation using a genetic algorithm under various weather conditions [PDF]
, 2014 Growing water scarcity, due to growing populations and varying natural conditions, puts pressure on irrigation systems, which often are the main consumptive water users.
Ghahraman, Bijan +4 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Evaluating the Sustainability of Wheat–Maize System with a Long-Term Fertilization Experiment
AgronomyIn light of the issue concerning excessive fertilization that prevails in the Huang-Huai-Hai Plain, through conducting a 13-year long-term positioning experiment, the sustainability of a wheat and maize double-cropping soil system under different ...
Yun Shao +6 more
doaj +1 more source