Results 61 to 70 of about 483,239 (310)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A meta-analysis of the effects of crop residue return on crop yields and water use efficiency.
PLoS ONE, 2020 After harvesting agricultural crops, the residue can be returned to the soil as mulch. This study performed a meta-analysis of previous research to investigate the effects of crop residue return and other factors on crop yields and water use efficiency ...
Xingli Lu
doaj +1 more source
Corn Cropping Systems to Improve Economic and Environmental Health [PDF]
, 2014 In 2014, UVM Extension’s Northwest Crops & Soils Program initiated a trial at Borderview Research Farm in Alburgh, VT to assess the impact of corn cropping systems on overall health and productivity of the crop and soil.
Cummings, Erica +5 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Comparison of two soil tillage treatments for winter barley-soybean growing based only on residual nitrogen after soybean [PDF]
, 2008 The winter barley crop growing has not been adequately researched regarding soil tillage systems, especially in crop rotation with the soybean, both crops gaining importance as food or fodder.
Babic, D. +6 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Corn Cropping Systems to Improve Economic and Environmental Health [PDF]
, 2017 In 2017, UVM Extension’s Northwest Crops & Soils Program continued a multi-year trial at Borderview Research Farm in Alburgh, VT to assess the impact of corn cropping systems on overall health and productivity of the crop and soil.
Cubins, Julija +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source