Results 81 to 90 of about 162,634 (303)

Territorial Impact Assessment and Cross-Border Cooperation [PDF]

Regional Studies, Regional Science, 2015
Impact Assessment procedures have gained increasing attention from the European Commission (EC), as fundamental tools in providing evidence of the potential impacts of European Union (EU) financed projects/programmes/policies. Yet, only recently, the Territorial Impact Assessment (TIA) of EU directives and Policies have gained a broader support from ...
openaire   +2 more sources

Accessibility Dynamics and Regional Cross-Border Cooperation (CBC) Perspectives in the Portuguese—Spanish Borderland

Sustainability, 2020
Accessibility plays a major role in achieving sustainable transport, and therefore urban and regional sustainability. The urban public transport system promotes mobility and realizes a large part of urban movements.
Ana Vulevic, R. Castanho, José Manuel Naranjo Gómez, L. Loures, J. Cabezas, L. Fernández-Pozo, José Martín Gallardo   +6 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Reimagining Cross-Border Cooperation From Indonesia-Malaysia Experiences: A Thematic Literature Review

Journal of ASEAN Studies
The research aimed to explore the scientific discourse of cross-border cooperation in Southeast Asia, particularly on the Indonesia-Malaysia border area.
Sandy Nur Ikfal Raharjo, Hanizah Idris
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Features of St. Petersburg and South-Eastern Finland Cross-Border Cooperation

Управленческое консультирование, 2018
Cross-border cooperation between Finland and Russia is one of the priorities of international integration relations between our country and the European Union.
Nikolai Maratovich Mezhevich, Veronika Vladimirovna Spiridonova   +1 more
doaj   +1 more source

Euroregions and Local and Regional Development—Local Perceptions of Cross-Border Cooperation and Euroregions Based on the Euroregion Beskydy

Sustainability, 2020
The cross-border regions, which are the peripheral regions, are struggling with m troubles. They often include high unemployment, insufficiently developed infrastructure, or inadequate language skills of residents, which are barriers to exploiting the ...
Honorata Howaniec, M. Lis
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source