Results 141 to 150 of about 9,045,544 (280)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Things that make Stan cross [picture] : contending with the county council /

, 1900
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; "Stan Cross"--In ink, lower right. "Page 5"--In ink, on note attached to verso.; Title devised by cataloguer.; Also available in an electronic version via the internet at: http://nla ...
Cross, Stan, 1888-1977.
core  

Why condition cash transfers? A multimethod pilot study evaluating the conditioning of cash transfers for tuberculosis treatment. [PDF]

BMC Health Serv Res
Forse R, Nguyen TT, Codlin AJ, Vo LNQ, Nguyen L, Nguyen N, Wiemers AMC, Hoang LA, Dao TP, Minh HDT, Nguyen LH, Nguyen HB, Van Luong D, Nguyen NV, Caws M, Wingfield T, Lönnroth K, Sidney-Annerstedt K.   +17 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Public institutions for cleantech commercialization in the United States. [PDF]

Nat Commun
Finkelstine E, Diaz Anadon L, Meckling J.   +2 more
europepmc   +1 more source

The IMF and Economic Development

, 2003
J. Vreeland
semanticscholar   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Beyond the Transplanted: Who Should Inform Attitudes Toward Xenotransplantation? [PDF]

Xenotransplantation
McDonnell JL, Pomales TO, Tanaka T.
europepmc   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Legitimacy, embedding, and learning framework: lessons from individual placement and support for analyzing sustainment and scale-up of complex psychosocial interventions. [PDF]

Int J Public Health
Harkko J.
europepmc   +1 more source